Epernicus: Jiyoun Lee, Ph.D.

Jiyoun Lee, Ph.D.

Position:
Post Doctoral Fellow

Pathology

Stanford University School of Medicine (Stanford, CA)
Advisor:
Matthew Bogyo
Degrees:

Ph.D., Chemistry, Northwestern University (Evanston, IL)

M.S., Medicinal Chemistry, Seoul National University (Seoul, Republic of Korea)

B.Sc., Pharmacy, Seoul National University (Seoul, Republic of Korea)
Past Advisors:

Christopher J. Chang (as Post Doctoral Fellow)

Thomas J Meade (as Graduate Student - Ph.D.)

Jeewoo Lee (as Graduate Student - Masters)
Research:
I am currently working on the development of the activity based probes for lysosomal and matrix proteases and their application for in vivo imaging.

Communities:

Jiyoun Lee's Genealogy

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Jiyoun Lee's Publications (11)

Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agents.
Lee J, Burdette JE, MacRenaris KW, Mustafi D, Woodruff TK, Meade TJ

Chemistry & biology. 2007 Jul;14(7):824-34
A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.
Lee J, Zylka MJ, Anderson DJ, Burdette JE, Woodruff TK, Meade TJ

Journal of the American Chemical Society. 2005 Sep 28;127(38):13164-6
Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.
Lee J, Jin MK, Kang SU, Kim SY, Lee J, Shin M, Hwang J, Cho S, Choi YS, Choi HK, Kim SE, Suh YG, Lee YS, Kim YH, Ha HJ, Toth A, Pearce LV, Tran R, Szabo T, Welter JD, Lundberg DJ, Wang Y, Lazar J, Pavlyukovets VA, Morgan MA, Blumberg PM

Bioorganic & medicinal chemistry letters. 2005 Sep 15;15(18):4143-50
Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism.
Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK, Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM

Bioorganic & medicinal chemistry. 2004 Jul 1;12(13):3411-20
Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic acti
Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, Wang Y, Toth A, Blumberg PM

Bioorganic & medicinal chemistry letters. 2004 May 3;14(9):2291-7
Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.
Lee J, Kim SY, Park S, Lim JO, Kim JM, Kang M, Lee J, Kang SU, Choi HK, Jin MK, Welter JD, Szabo T, Tran R, Pearce LV, Toth A, Blumberg PM

Bioorganic & medicinal chemistry. 2004 Mar 1;12(5):1055-69
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.
Park HG, Choi JY, Choi SH, Park MK, Lee J, Suh YG, Cho H, Oh U, Lee J, Kang SU, Lee J, Kim HD, Park YH, Su Jeong Y, Kyu Choi J, Jew SS

Bioorganic & medicinal chemistry letters. 2004 Feb 9;14(3):787-91
High-affinity partial agonists of the vanilloid receptor.
Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J

Molecular pharmacology. 2003 Aug;64(2):325-33
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.
Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, Toth A, Wang Y, Tran R, Pearce LV, Lundberg DJ, Blumberg PM

Journal of medicinal chemistry. 2003 Jul 3;46(14):3116-26
High affinity antagonists of the vanilloid receptor.
Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J

Molecular pharmacology. 2002 Oct;62(4):947-56
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics.
Lee J, Lee J, Kang MS, Kim KP, Chung SJ, Blumberg PM, Yi JB, Park YH

Bioorganic & medicinal chemistry. 2002 Apr;10(4):1171-9

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Jiyoun Lee, Ph.D.

Post Doctoral Fellow

I am currently working on the development of the activity based probes for lysosomal and matrix proteases and their application for in vivo imaging.

Jiyoun Lee's Genealogy

Jiyoun Lee's Publications (11)