Epernicus: Jehyuk Lee, M.D., Ph.D.

Jehyuk Lee, M.D., Ph.D.

Position:
Research Fellow

Genetics

Wyss Institute for Biologically Inspired Engineering

Harvard Medical School (Boston, MA)
Advisor:
George M Church
Degrees:

M.D., Internal Medicine, Tufts Medical Center (Boston, MA)

Ph.D., Cellular and Molecular Physiology, Tufts University (Medford, MA)

B.S., Biochemistry, University of Pennsylvania (Philadelphia, PA)
Clinical Training:

Residency, Internal Medicine, Hospital of the University of Pennsylvania
Past Advisors:

Brent H Cochran (as Graduate Student - Ph.D.)
Research:
Developing genetic experimental tools and artificial tissue engineering technologies for analyzing and human complex traits and phenotypes.

I am developing open and scalable methods for collecting, reprogramming and manipulating a large population of human cohorts for functional studies. Ultra-affordable methods for deriving cell lines from humans, deriving induced pluripotent stem cells and sequencing both DNA and RNA transcriptome using deep sequencing technologies should enable accelerate discoveries in human genetics. In addition, I am using synthetic biology approaches to engineer human embryonic stem cells that can be integrated with microfluidic and electronic circuits devices as an alternative to raw tissue engineering.

Communities:

The Adobe Flash Player plugin (version 8) is required to view the genealogy tree.
Download the plugin here.

A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.
Lee JH, Park IH, Gao Y, Li JB, Li Z, Daley GQ, Zhang K, Church GM

PLoS genetics. 2009 Nov;5(11):e1000718
Generation of functional human hepatic endoderm from human induced pluripotent stem cells.
Sullivan GJ, Hay DC, Park IH, Fletcher J, Hannoun Z, Payne CM, Dalgetty D, Black JR, Ross JA, Samuel K, Wang G, Daley GQ, Lee JH, Church GM, Forbes SJ, Iredale JP, Wilmut I

Hepatology (Baltimore, Md.). 2009 Sep 29
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human.
Zhang K, Li JB, Gao Y, Egli D, Xie B, Deng J, Li Z, Lee JH, Aach J, Leproust EM, Eggan K, Church GM

Nature methods. 2009 Aug;6(8):613-8
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.
Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM

Nature biotechnology. 2009 Apr;27(4):361-8
Rapid activation of latent transcription factor complexes reflects initiating signals in liver regeneration.
Marie Scearce L, Lee J, Naji L, Greenbaum L, Cressman DE, Taub R

Cell death and differentiation. 1996 Jan;3(1):47-55
Structure and localization of the IGFBP-1 gene and its expression during liver regeneration.
Lee J, Greenbaum L, Haber BA, Nagle D, Lee V, Miles V, Mohn KL, Bucan M, Taub R

Hepatology (Baltimore, Md.). 1994 Mar;19(3):656-65

Join Epernicus (membership is free)

Epernicus is open to current and former research scientists.

Already a member?
Sign in to view Jehyuk's full profile.