Assistant Professor

Chemical and Systems Biology

Chemistry (by courtesy)

Stanford University School of Medicine (Stanford, CA)

Faculty Director, Stanford High-Throughput Bioscience Center

Stanford University School of Medicine (Stanford, CA)

Our laboratory integrates chemistry and developmental biology to interrogate the molecular mechanisms of tissue formation, function, and regeneration.

Our laboratory uses an interdisciplinary approach to investigate how tissue patterning and function is regulated at the molecular level. Our research efforts have focused on Hedgehog signaling, and we have identified several small molecules and genes that regulate this developmental and oncogenic pathway. Understanding the biochemical mechanisms of these pathway modulators is a major goal of our research group. We are concurrently using zebrafish models to study how the Hedgehog pathway and other signaling processes act in space and time to regulate embryogenesis and tissue regeneration. As part of our efforts toward this goal, we have developed chemical systems that enable spatiotemporal regulation of gene expression in this organism. We are also working toward new technologies that will facilitate the imaging of gene expression and protein function in vivo.

1998 Summer Course in Embryology, Marine Biological Laboratory, Woods Hole

2008-2013 NIH Director's Pioneer Award

2008-2011 American Cancer Society Research Scholar Award

2006-2008 Brain Tumor Society Award

2006 Faculty Fellow, Stanford University School of Medicine

2005 Astellas USA Foundation Award

2005-2008 Terman Fellow, Stanford University

2005-2007 March of Dimes Basil O'Connor Starter Scholar Research Award

2004-2006 Kimmel Scholar Award

2003 W. Barry Wood, Jr. Postdoctoral Research Award

2002-2003 American Cancer Society Postdoctoral Fellowship

1999-2002 Damon Runyon-Walter Winchell Postdoctoral Fellowship

1994-1995 American Chemical Society Predoctoral Fellowship

1991-1994 National Science Foundation Predoctoral Fellowship