Epernicus: Jeffrey J Brault, Ph.D.

Jeffrey J Brault, Ph.D.

Positions:
Assistant Professor

Exercise and Sport Science

East Carolina University (Greenville, NC)

Assistant Professor

Physiology

Biochemistry and Molecular Biology

East Carolina University Brody School of Medicine (Greenville, NC)
Degrees:

Ph.D., Physiology, University of Missouri (Columbia, MO)

B.Sc., Medical Technology, Marquette University (Milwaukee, WI)
Past Advisors:

Alfred L Goldberg (as Post Doctoral Fellow)

Ronald L Terjung (as Graduate Student - Ph.D.)
Research:
Cellular energetics and the control of muscle atrophy
Other Experience:
1992-1995 Staff Medical Technologist, Blood bank, The Johns Hopkins Hospital

Communities:

Jeffrey Brault's Genealogy

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Jeffrey Brault's Publications (13)

Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.
Brault JJ, Jespersen JG, Goldberg AL

The Journal of biological chemistry. 2010 Jun 18;285(25):19460-71
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.
Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, Goldberg AL

The Journal of cell biology. 2009 Jun 15;185(6):1083-95
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.
Zhao J, Brault JJ, Schild A, Goldberg AL

Autophagy. 2008 Apr 1;4(3):378-80
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.
Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL

Cell metabolism. 2007 Dec;6(6):472-83
Parallel increases in phosphocreatine and total creatine in human vastus lateralis muscle during creatine supplementation.
Brault JJ, Towse TF, Slade JM, Meyer RA

International journal of sport nutrition and exercise metabolism. 2007 Dec;17(6):624-34
Protecting the cellular energy state during contractions: role of AMP deaminase.
Hancock CR, Brault JJ, Terjung RL

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2006 Nov;57 Suppl 10:17-29
31P-NMR observation of free ADP during fatiguing, repetitive contractions of murine skeletal muscle lacking AK1.
Hancock CR, Brault JJ, Wiseman RW, Terjung RL, Meyer RA

American journal of physiology. Cell physiology. 2005 Jun;288(6):C1298-304
Phosphate uptake and PiT-1 protein expression in rat skeletal muscle.
Abraham KA, Brault JJ, Terjung RL

American journal of physiology. Cell physiology. 2004 Jul;287(1):C73-8
Creatine uptake and creatine transporter expression among rat skeletal muscle fiber types.
Brault JJ, Terjung RL

American journal of physiology. Cell physiology. 2003 Jun;284(6):C1481-9
Muscle creatine uptake and creatine transporter expression in response to creatine supplementation and depletion.
Brault JJ, Abraham KA, Terjung RL

Journal of applied physiology (Bethesda, Md. : 1985). 2003 Jun;94(6):2173-80
Phosphocreatine content of freeze-clamped muscle: influence of creatine kinase inhibition.
Brault JJ, Abraham KA, Terjung RL

Journal of applied physiology (Bethesda, Md. : 1985). 2003 May;94(5):1751-6
Influence of ribose on adenine salvage after intense muscle contractions.
Zarzeczny R, Brault JJ, Abraham KA, Hancock CR, Terjung RL

Journal of applied physiology (Bethesda, Md. : 1985). 2001 Oct;91(4):1775-81
Purine salvage to adenine nucleotides in different skeletal muscle fiber types.
Brault JJ, Terjung RL

Journal of applied physiology (Bethesda, Md. : 1985). 2001 Jul;91(1):231-8

Websites

Alfred Goldberg Lab Page

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