Director of Labatory and Manufacturing

Ligon Discovery (Cambridge, MA)

I study small molecule - protein interactions though primary small molecule microarray screens of oncogenic proteins, computational distribution analysis to identify the novel protein binders, and secondary (SPR and/or HTS) assays to fully characterize possible therapeutic and diagnostic compounds.

My primary focus is searching for HDAC specific modulators. I have screened 11 Histone Deacetylases (HDACs) against 20,000 compounds on SMMs, modeled the data, and hand pick hits. I am in the process of running follow up assays to characterize compound activity. I'm also currently in working toward a more statistically robust to choose hits.
I also work on similar smaller scale NCI focused SMM screens and mentor some of our collaborators in running their own SMM screens.

2006-2009 Research Associate II, Broad Institute of MIT and Harvard, Chemical Biology Program; Small Molecule Microarrays

2004-2005 Validation Specialist, IPS (Aventis, Schering Plough, and J B Williams Co Inc )

2003-2004 Consultant (Documentation, Engineering, and Production) , Johnson & Johnson

2003 Cleaning Validation Engineer (Consultant), AmGen

2002 Research Assistant I, ArQule

2001 Summer Intern (Fermentation Production & Bioreactor Validation), BASF / Abbot Labs

2000 QC Intern (Microbiology and Radiometrics), DuPont Pharmaceuticals - Medical Imaging

1998-1999 QC Chemist, DuPont-Merck Medical Imaging

1998 QC Chemistry Intern, DuPont-Merck Medical Imaging

1997 IT Helpdesk Summer Intern, DuPont-Merck Medical Imageing