Epernicus: Jerome Hert, Ph.D.

Jerome Hert, Ph.D.

Positions:
Research Scientist

CAMM Group

F. Hoffmann-La Roche, Ltd. (Basel, Switzerland)

Post Doctoral Fellow

Pharmaceutical Chemistry

University of California, San Francisco (San Francisco, CA)

Post Doctoral Fellow

Department of Pharmacy

Louis Pasteur University (Strasbourg, France)
Advisor:
Didier Rognan
Degrees:

Ph.D., Chemoinformatics, University of Sheffield (Sheffield, UK)

M.Sc., Chemoinformatics, University of Strasbourg (Strasbourg, France)

B.Sc., Chemistry, University of Strasbourg (Strasbourg, France)
Past Advisors:

Brian K Shoichet (as Post Doctoral Fellow)

Peter Willett (as Graduate Student - Ph.D.)
Research:
I am currently interested in relating proteins through the statistical similarity of their ligands. The idea is to use the chemical similarity among ligand-sets as a proxy to the pharmacological similarities of the protein targets.
Other Experience:
Honors:
2007-2009 Marie Curie Outgoing International Fellowship

2005 CINF-IO Informatics Scholarship for scientific excellence

Communities:

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Quantifying the relationships among drug classes.
Hert J, Keiser MJ, Irwin JJ, Oprea TI, Shoichet BK

Journal of chemical information and modeling. 2008 Apr;48(4):755-65
New methods for ligand-based virtual screening: use of data fusion and machine learning to enhance the effectiveness of similarity searching.
Hert J, Willett P, Wilton DJ, Acklin P, Azzaoui K, Jacoby E, Schuffenhauer A

Journal of chemical information and modeling. 2006 Mar-Apr;46(2):462-70
Enhancing the effectiveness of similarity-based virtual screening using nearest-neighbor information.
Hert J, Willett P, Wilton DJ, Acklin P, Azzaoui K, Jacoby E, Schuffenhauer A

Journal of medicinal chemistry. 2005 Nov 3;48(22):7049-54
Ligand-based virtual screening using binary kernel discrimination
C Beining, R F Harrison, Jerome Hert, C Mpanhanga, P Willett, D J Wilton

Molecular Simulation. 2005;31(8):597-604
Comparison of topological descriptors for similarity-based virtual screening using multiple bioactive reference structures.
Hert J, Willett P, Wilton DJ, Acklin P, Azzaoui K, Jacoby E, Schuffenhauer A

Organic & biomolecular chemistry. 2004 Nov 21;2(22):3256-66
Comparison of fingerprint-based methods for virtual screening using multiple bioactive reference structures.
Hert J, Willett P, Wilton DJ, Acklin P, Azzaoui K, Jacoby E, Schuffenhauer A

Journal of chemical information and computer sciences. 2004 May-Jun;44(3):1177-85

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