Epernicus: Jason E Hill, Ph.D.

Jason E Hill, Ph.D.

Position:
Associate Director, External Science Affairs

Central Labs

Quintiles (Durham, NC)
Degrees:

Ph.D., Molecular Genetics, University of Illinois at Chicago (Chicago, IL)

M.S., Biochemistry, Thomas Jefferson University Jefferson Medical College (Philadelphia, PA)

B.S., Biology, University of Scranton (Scranton, PA)
Past Advisors:

Ram Ganapathi (as Post Doctoral Fellow)

Andrei V Gudkov (as Graduate Student - Ph.D.)
Research:

Communities:

Jason Hill's Genealogy

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Jason Hill's Publications (12)

Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.
Vaziri SA, Grabowski DR, Hill J, Rybicki LR, Burk R, Bukowski RM, Ganapathi MK, Ganapathi R

Anticancer research. 2009 Aug;29(8):2961-9
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells.
Spector NL, Yarden Y, Smith B, Lyass L, Trusk P, Pry K, Hill JE, Xia W, Seger R, Bacus SS

Proceedings of the National Academy of Sciences of the United States of America. 2007 Jun 19;104(25):10607-12
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Chikamori K, Hill JE, Grabowski DR, Zarkhin E, Grozav AG, Vaziri SA, Wang J, Gudkov AV, Rybicki LR, Bukowski RM, Yen A, Tanimoto M, Ganapathi MK, Ganapathi R

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2006 Oct;20(10):1809-18
Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice.
Burdelya LG, Komarova EA, Hill JE, Browder T, Tararova ND, Mavrakis L, DiCorleto PE, Folkman J, Gudkov AV

Cancer research. 2006 Oct 1;66(19):9356-61
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.
Xia W, Bacus S, Hegde P, Husain I, Strum J, Liu L, Paulazzo G, Lyass L, Trusk P, Hill J, Harris J, Spector NL

Proceedings of the National Academy of Sciences of the United States of America. 2006 May 16;103(20):7795-800
Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.
Vaziri SA, Hill J, Chikamori K, Grabowski DR, Takigawa N, Chawla-Sarkar M, Rybicki LR, Gudkov AV, Mekhail T, Bukowski RM, Ganapathi MK, Ganapathi R

Molecular cancer therapeutics. 2005 Dec;4(12):1880-90
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.
Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova E, Khodyakova AV, Ganapathi R, Ganapathi M, Tararova ND, Bosykh D, Lvovskiy D, Webb TR, Stark GR, Gudkov AV

Proceedings of the National Academy of Sciences of the United States of America. 2005 Nov 29;102(48):17448-53
Down-regulation of p53 by double-stranded RNA modulates the antiviral response.
Marques JT, Rebouillat D, Ramana CV, Murakami J, Hill JE, Gudkov A, Silverman RH, Stark GR, Williams BR

Journal of virology. 2005 Sep;79(17):11105-14
p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.
Gurova KV, Hill JE, Razorenova OV, Chumakov PM, Gudkov AV

Cancer research. 2004 Mar 15;64(6):1951-8
Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function.
Zeremski M, Hill JE, Kwek SS, Grigorian IA, Gurova KV, Garkavtsev IV, Diatchenko L, Koonin EV, Gudkov AV

The Journal of biological chemistry. 1999 Nov 5;274(45):32172-81
PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori.
Akopyants NS, Fradkov A, Diatchenko L, Hill JE, Siebert PD, Lukyanov SA, Sverdlov ED, Berg DE

Proceedings of the National Academy of Sciences of the United States of America. 1998 Oct 27;95(22):13108-13
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.
Komarova EA, Diatchenko L, Rokhlin OW, Hill JE, Wang ZJ, Krivokrysenko VI, Feinstein E, Gudkov AV

Oncogene. 1998 Sep 3;17(9):1089-96

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Jason E Hill, Ph.D.

Associate Director, External Science Affairs

Jason Hill's Genealogy

Jason Hill's Publications (12)