Epernicus: Jacob E Corn, Ph.D.

Jacob E Corn, Ph.D.

Position:
scientist

Early Discovery Biochemistry

Genentech, Inc. (South San Francisco, CA)
Degrees:

Ph.D., Structural biology, University of California, Berkeley (Berkeley, CA)

B.Sc., Biology, University of Puget Sound (Tacoma, WA)
Past Advisors:

David Baker (as Post Doctoral Fellow)

James M Berger (as Graduate Student - Ph.D.)
Research:
Computational design of eukaryotic signal transduction.
Honors:
2008-2010 Jane Coffin Childs Memorial Fund postdoctoral fellow

2008 Harold M. Weintraub graduate student award

2008 Nicholas Cozzarelli graduate student award

Communities:

Jacob Corn's Genealogy

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Jacob Corn's Publications (15)

Computational design of proteins targeting the conserved stem region of influenza hemagglutinin.
Fleishman SJ, Whitehead TA, Ekiert DC, Dreyfus C, Corn JE, Strauch EM, Wilson IA, Baker D

Science (New York, N.Y.). 2011 May 13;332(6031):816-21
Molecular determinants of origin discrimination by Orc1 initiators in archaea.
Dueber EC, Costa A, Corn JE, Bell SD, Berger JM

Nucleic acids research. 2011 May 1;39(9):3621-31
A de novo protein binding pair by computational design and directed evolution.
Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D

Molecular cell. 2011 Apr 22;42(2):250-60
ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules.
Leaver-Fay A, Tyka M, Lewis SM, Lange OF, Thompson J, Jacak R, Kaufman K, Renfrew PD, Smith CA, Sheffler W, Davis IW, Cooper S, Treuille A, Mandell DJ, Richter F, Ban YE, Fleishman SJ, Corn JE, Kim DE, Lyskov S, Berrondo M, Mentzer S, Popović Z, Havranek JJ, Karanicolas J, Das R, Meiler J, Kortemme T, Gray JJ, Kuhlman B, Baker D, Bradley P

Methods in enzymology. 2011;487:545-74
Rosetta in CAPRI rounds 13-19.
Fleishman SJ, Corn JE, Strauch EM, Whitehead TA, Andre I, Thompson J, Havranek JJ, Das R, Bradley P, Baker D

Proteins. 2010 Nov 15;78(15):3212-8
Automated electron-density sampling reveals widespread conformational polymorphism in proteins.
Lang PT, Ng HL, Fraser JS, Corn JE, Echols N, Sales M, Holton JM, Alber T

Protein science : a publication of the Protein Society. 2010 Jul;19(7):1420-31
THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves.
Sabogal A, Lyubimov AY, Corn JE, Berger JM, Rio DC

Nature structural & molecular biology. 2010 Jan;17(1):117-23
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
Tesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T

Journal of neurochemistry. 2009 Aug;110(4):1254-62
Structure, stability, and folding of ribonuclease H1 from the moderately thermophilic Chlorobium tepidum: comparison with thermophilic and mesophilic homologues.
Ratcliff K, Corn J, Marqusee S

Biochemistry. 2009 Jun 30;48(25):5890-8
Hyperthermophilic Aquifex aeolicus initiates primer synthesis on a limited set of trinucleotides comprised of cytosines and guanines.
Larson MA, Bressani R, Sayood K, Corn JE, Berger JM, Griep MA, Hinrichs SH

Nucleic acids research. 2008 Sep;36(16):5260-9
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis.
Corn JE, Pelton JG, Berger JM

Nature structural & molecular biology. 2008 Feb;15(2):163-9
Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex.
Dueber EL, Corn JE, Bell SD, Berger JM

Science (New York, N.Y.). 2007 Aug 31;317(5842):1210-3
FASTDXL: a generalized screen to trap disulfide-stabilized complexes for use in structural studies.
Corn JE, Berger JM

Structure (London, England : 1993). 2007 Jul;15(7):773-80
Regulation of bacterial priming and daughter strand synthesis through helicase-primase interactions.
Corn JE, Berger JM

Nucleic acids research. 2006;34(15):4082-8
Crosstalk between primase subunits can act to regulate primer synthesis in trans.
Corn JE, Pease PJ, Hura GL, Berger JM

Molecular cell. 2005 Nov 11;20(3):391-401

One Figure

C10-Pdar

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Jacob E Corn, Ph.D.

scientist

Computational design of eukaryotic signal transduction.

Jacob Corn's Genealogy

Jacob Corn's Publications (15)

One Figure