Epernicus: Johannes CM Vanderloo, Ph.D.

Johannes CM Vanderloo, Ph.D.

Positions:
Associate Professor

Experimental Hematology and Cancer Biology

Translational Cores

Cincinnati Children's Hospital Research Foundation (Cincinnati, Ohio)

Director, Aseptic Processing Laboratories

Cincinnati Children's Hospital Research Foundation (Cincinnati, Ohio)

Director, Vector Production Facility

Cincinnati Children's Hospital Research Foundation (Cincinnati, Ohio)

Chair, Institutional Biosafety Committee

Cincinnati Children's Hospital Research Foundation (Cincinnati, Ohio)
Degrees:

Ph.D., Hematology, Erasmus University Rotterdam (Rotterdam, Netherlands)
Past Advisors:
Research:
Manufacturing of Viral Vectors for early phase clinical trials in compliance with current Good Manufacturing Practices

Communities:

Johannes Vanderloo's Genealogy

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Johannes Vanderloo's Publications (21)

Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells.
Schambach A, Swaney WP, van der Loo JC

Methods in molecular biology (Clifton, N.J.). 2009;506:191-205
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
Suzuki T, Sakagami T, Rubin BK, Nogee LM, Wood RE, Zimmerman SL, Smolarek T, Dishop MK, Wert SE, Whitsett JA, Grabowski G, Carey BC, Stevens C, van der Loo JC, Trapnell BC

The Journal of experimental medicine. 2008 Nov 24;205(12):2703-10
PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection.
Carey B, Staudt MK, Bonaminio D, van der Loo JC, Trapnell BC

Journal of immunology (Baltimore, Md. : 1950). 2007 Feb 15;178(4):2440-7
Homing defect of cultured human hematopoietic cells in the NOD/SCID mouse is mediated by Fas/CD95.
Liu B, Buckley SM, Lewis ID, Goldman AI, Wagner JE, van der Loo JC

Experimental hematology. 2003 Sep;31(9):824-32
Optimization of gene transfer into primitive human hematopoietic cells of granulocyte-colony stimulating factor-mobilized peripheral blood using low-dose cytokines and comparison of a gibbon ape leukemia virus versus an RD114-pseudotyped retroviral vector
van der Loo JC, Liu BL, Goldman AI, Buckley SM, Chrudimsky KS

Human gene therapy. 2002 Jul 20;13(11):1317-30
Differential transduction efficiency of SCID-repopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood.
Pollok KE, van Der Loo JC, Cooper RJ, Hartwell JR, Miles KR, Breese R, Williams EP, Montel A, Seshadri R, Hanenberg H, Williams DA

Human gene therapy. 2001 Nov 20;12(17):2095-108
Costimulation of transduced T lymphocytes via T cell receptor-CD3 complex and CD28 leads to increased transcription of integrated retrovirus.
Pollok KE, van der Loo JC, Cooper RJ, Kennedy L, Williams DA

Human gene therapy. 1999 Sep 1;10(13):2221-36
Simultaneous infection with retroviruses pseudotyped with different envelope proteins bypasses viral receptor interference associated with colocalization of gp70 and target cells on fibronectin CH-296.
MacNeill EC, Hanenberg H, Pollok KE, van der Loo JC, Bierhuizen MF, Wagemaker G, Williams DA

Journal of virology. 1999 May;73(5):3960-7
Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice.
Gothot A, van der Loo JC, Clapp DW, Srour EF

Blood. 1998 Oct 15;92(8):2641-9
Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells.
van der Loo JC, Hanenberg H, Cooper RJ, Luo FY, Lazaridis EN, Williams DA

Blood. 1998 Oct 1;92(7):2556-70
VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin.
van der Loo JC, Xiao X, McMillin D, Hashino K, Kato I, Williams DA

The Journal of clinical investigation. 1998 Sep 1;102(5):1051-61
Use of ER-MP12 as a positive marker for the isolation of murine long-term in vitro repopulating stem cells.
van der Loo JC, Slieker WA, Ploemacher RE

Experimental hematology. 1995 Aug;23(9):1002-10
Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors.
van der Loo JC, Ploemacher RE

Blood. 1995 May 1;85(9):2598-606
Identification of hematopoietic stem cell subsets on the basis of their primitiveness using antibody ER-MP12.
van der Loo JC, Slieker WA, Kieboom D, Ploemacher RE

Blood. 1995 Feb 15;85(4):952-62
Distinct mouse bone marrow macrophage precursors identified by differential expression of ER-MP12 and ER-MP20 antigens.
de Bruijn MF, Slieker WA, van der Loo JC, Voerman JS, van Ewijk W, Leenen PJ

European journal of immunology. 1994 Oct;24(10):2279-84
Stable multilineage hematopoietic chimerism in alpha-thalassemic mice induced by a bone marrow subpopulation that excludes the majority of day-12 spleen colony-forming units.
van der Loo JC, van den Bos C, Baert MR, Wagemaker G, Ploemacher RE

Blood. 1994 Apr 1;83(7):1769-77
ER-MP12 antigen, a new cell surface marker on mouse bone marrow cells with thymus-repopulating ability: II. Thymus-homing ability and phenotypic characterization of ER-MP12-positive bone marrow cells.
Slieker WA, van der Loo JC, de Rijk-de Bruijn MF, Godfrey DI, Leenen PJ, van Ewijk W

International immunology. 1993 Sep;5(9):1099-107
Wheat germ agglutinin affinity of murine hemopoietic stem cell subpopulations is an inverse function of their long-term repopulating ability in vitro and in vivo.
Ploemacher RE, van der Loo JC, van Beurden CA, Baert MR

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1993 Jan;7(1):120-30
In vitro assays for primitive hematopoietic cells.
Ploemacher RE, Van der Loo JC, Van der Sluijs JP

Blood. 1992 Feb 1;79(3):834-7
Aromatase, estrogen 2-hydroxylase, and catechol-O-methyltransferase activity in isolated, cultured gonadotropic cells of mature African catfish, Clarias gariepinus (Burchell).
de Leeuw R, Smit-van Dijk W, Zigterman JW, van der Loo JC, Lambert JG, Goos HJ

General and comparative endocrinology. 1985 Nov;60(2):171-7
Steroid aromatase, 2-hydroxylase and COMT activity in gonadotropic cells of the African catfish, Clarias gariepinus.
Goos HJ, van der Loo JC, Smit-van Dijk W, de Leeuw R

Cell biology international reports. 1985 Jun;9(6):529

One Figure

Open Manipulation in cGMP Vector Production Facility

Websites

Vector Production Facility

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