Epernicus: Isabelle Isnardi, Ph.D.

Isabelle Isnardi, Ph.D.

Position:
Post Doctoral Fellow

Research

Hospital for Special Surgery (New York, NY)
Advisor:
Eric Meffre
Degrees:

Ph.D., Immunology, Institut Pasteur (Paris, France), Pierre and Marie Curie University (Paris, France)

M.Sc., Immunology, Institut Pasteur (Paris, France), Pierre and Marie Curie University (Paris, France)

B.Sc., Molecular and Cellular Biology, Ecole Normale Superieure De Lyon (Lyon, France)
Past Advisors:

Marc Daeron (as Graduate Student - Ph.D.)
Research:
Characterization of the defective B cell tolerance mechanisms in patients suffering from autoimmune diseases and primary immunodeficiencies.
Other Experience:
2001-2004 Teaching Assistant in Immunology

Communities:

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IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans.
Isnardi I, Ng YS, Srdanovic I, Motaghedi R, Rudchenko S, von Bernuth H, Zhang SY, Puel A, Jouanguy E, Picard C, Garty BZ, Camcioglu Y, Doffinger R, Kumararatne D, Davies G, Gallin JI, Haraguchi S, Day NK, Casanova JL, Meffre E

Immunity. 2008 Nov;29(5):746-57
CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance.
Hervé M, Isnardi I, Ng YS, Bussel JB, Ochs HD, Cunningham-Rundles C, Meffre E

The Journal of experimental medicine. 2007 Jul 9;204(7):1583-93
The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation.
Isnardi I, Bruhns P, Bismuth G, Fridman WH, Daëron M

Immunology letters. 2006 Apr 15;104(1-2):156-65
Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.
Isnardi I, Lesourne R, Bruhns P, Fridman WH, Cambier JC, Daëron M

The Journal of biological chemistry. 2004 Dec 10;279(50):51931-8
Linker for activation of T cells integrates positive and negative signaling in mast cells.
Malbec O, Malissen M, Isnardi I, Lesourne R, Mura AM, Fridman WH, Malissen B, Daëron M

Journal of immunology (Baltimore, Md. : 1950). 2004 Oct 15;173(8):5086-94

Defective receptor editing results in the appearance of anergic B cells in humans (presentation)
Isabelle Isnardi

Keystone Meeting: B cells in context, Taos, USA; 02/2009
Human IRAK-4/MyD88-dependent receptors are essential for the removal of developing anti-nuclear B cells (presentation)
Isabelle Isnardi

French Society of Immunology Meeting, Lyon, France; 11/2007
IRAK-4 dependent Toll-like receptors are essential for the removal of human developing anti-nuclear B cells (poster)
Isabelle Isnardi

Keystone Meeting: Biology of B cells in Health and Disease, Banff, Canada; 02/2007
Critical role of adapter molecules in the recruitment of the inositol 5-phosphatases SHIP1 and SHIP2 by FcγRIIB (presentation)
Isabelle Isnardi

French Society of Immunology Meeting with Japan, Strasbourg, France; 11/2002

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