Epernicus: Israel Hanukoglu, Ph.D.

Israel Hanukoglu, Ph.D.

Position:
Professor

Molecular Biology

Ariel University Center of Samaria (Ariel, Israel)
Degrees:

Ph.D., University of Wisconsin-Madison (Madison, WI)

M.Sc., Endocrinology, University of Wisconsin-Madison (Madison, WI)

B.A., Biology, Psychology, Political Science, Hebrew University of Jerusalem (Jerusalem, Israel)
Past Advisors:

Elaine Fuchs (as Post Doctoral Fellow)

Colin R. Jefcoate (as Graduate Student - Ph.D.)

Harry J. Karavolas (as Graduate Student - Masters)

Robert W. Goy (as Graduate Student - Masters)
Research:
Structure-function relationships in Epithelial Sodium Channels (ENaC).
Other Experience:
1996-1999 Science Adviser to the Prime Minister of Israel
Honors:
1991 Lubell Prize by the Weizmann Institute of Science

1988 Hans Lindner Prize by the Israel Endocrine Society

Communities:

Israel Hanukoglu's Genealogy

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Israel Hanukoglu's Publications (51)

Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12.
Muhammad E, Leventhal N, Parvari G, Hanukoglu A, Hanukoglu I, Chalifa-Caspi V, Feinstein Y, Weinbrand J, Jacoby H, Manor E, Nagar T, Beck JC, Sheffield VC, Hershkovitz E, Parvari R

Human genetics. 2011 Apr;129(4):397-405
Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis.
Edelheit O, Hanukoglu I, Dascal N, Hanukoglu A

American journal of physiology. Renal physiology. 2011 Apr;300(4):F887-97
Clinical improvement in patients with autosomal recessive pseudohypoaldosteronism and the necessity for salt supplementation.
Hanukoglu A, Hanukoglu I

Clinical and experimental nephrology. 2010 Oct;14(5):518-9
Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC.
Edelheit O, Hanukoglu I, Shriki Y, Tfilin M, Dascal N, Gillis D, Hanukoglu A

The Journal of steroid biochemistry and molecular biology. 2010 Mar;119(1-2):84-8
Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies.
Edelheit O, Hanukoglu A, Hanukoglu I

BMC biotechnology. 2009;9:61
Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes.
Hanukoglu A, Edelheit O, Shriki Y, Gizewska M, Dascal N, Hanukoglu I

The Journal of steroid biochemistry and molecular biology. 2008 Sep;111(3-5):268-74
Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells.
Hanukoglu I

Drug metabolism reviews. 2006;38(1-2):171-96
Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multisystem pseudohypoaldosteronism.
Edelheit O, Hanukoglu I, Gizewska M, Kandemir N, Tenenbaum-Rakover Y, Yurdakök M, Zajaczek S, Hanukoglu A

Clinical endocrinology. 2005 May;62(5):547-53
ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells.
Reichenstein M, Reich R, LeHoux JG, Hanukoglu I

Molecular and cellular endocrinology. 2004 Feb 27;215(1-2):109-14
Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes.
Saxena A, Hanukoglu I, Saxena D, Thompson RJ, Gardiner RM, Hanukoglu A

The Journal of clinical endocrinology and metabolism. 2002 Jul;87(7):3344-50
Amiloride-sensitive epithelial sodium channel subunits are expressed in human and mussel immunocytes.
Ottaviani E, Franchini A, Mandrioli M, Saxena A, Hanukoglu A, Hanukoglu I

Developmental and comparative immunology. 2002 Jun;26(5):395-402
The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis.
Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE

Journal of molecular biology. 1999 Jun 18;289(4):981-90
Chaperone-assisted expression of authentic bovine adrenodoxin reductase in Escherichia coli.
Vonrhein C, Schmidt U, Ziegler GA, Schweiger S, Hanukoglu I, Schulz GE

FEBS letters. 1999 Jan 25;443(2):167-9
Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit.
Saxena A, Hanukoglu I, Strautnieks SS, Thompson RJ, Gardiner RM, Hanukoglu A

Biochemical and biophysical research communications. 1998 Nov 9;252(1):208-13
Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle.
Rapoport R, Sklan D, Wolfenson D, Shaham-Albalancy A, Hanukoglu I

Biochimica et biophysica acta. 1998 Mar 12;1380(1):133-40
In situ localization of ACTH receptor-like mRNA in molluscan and human immunocytes.
Ottaviani E, Franchini A, Hanukoglu I

Cellular and molecular life sciences : CMLS. 1998 Feb;54(2):139-42
Pseudohypoaldosteronism due to renal and multisystem resistance to mineralocorticoids respond differently to carbenoxolone.
Hanukoglu A, Joy O, Steinitz M, Rosler A, Hanukoglu I

The Journal of steroid biochemistry and molecular biology. 1997 Jan;60(1-2):105-12
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1.
Chang SS, Grunder S, Hanukoglu A, Rösler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelson-Williams C, Rossier BC, Lifton RP

Nature genetics. 1996 Mar;12(3):248-53
Localisation of pseudohypoaldosteronism genes to chromosome 16p12.2-13.11 and 12p13.1-pter by homozygosity mapping.
Strautnieks SS, Thompson RJ, Hanukoglu A, Dillon MJ, Hanukoglu I, Kuhnle U, Seckl J, Gardiner RM, Chung E

Human molecular genetics. 1996 Feb;5(2):293-9
Tissue- and species-dependent expression of sheep lung microsomal cytochrome P4502B(LgM2).
Arinç E, Hanukoglu I, Sen A, Adali O

Biochemistry and molecular biology international. 1995 Dec;37(6):1121-6
Exclusion of the locus for autosomal recessive pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis.
Chung E, Hanukoglu A, Rees M, Thompson R, Dillon M, Hanukoglu I, Bistritzer T, Kuhnle U, Seckl J, Gardiner RM

The Journal of clinical endocrinology and metabolism. 1995 Nov;80(11):3341-5
Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants.
Hanukoglu A, Fried D, Nakash I, Hanukoglu I

European journal of endocrinology / European Federation of Endocrine Societies. 1995 Nov;133(5):552-6
Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence.
Rapoport R, Sklan D, Hanukoglu I

Archives of biochemistry and biophysics. 1995 Mar 10;317(2):412-6
Routes and regulation of NADPH production in steroidogenic mitochondria.
Hanukoglu I, Rapoport R

Endocrine research. 1995 Feb-May;21(1-2):231-41
Cloning of ACTH-regulated genes in the adrenal cortex.
Raikhinstein M, Hanukoglu I

The Journal of steroid biochemistry and molecular biology. 1994 Jun;49(4-6):257-60

Israel Hanukoglu, Ph.D.

Professor

Structure-function relationships in Epithelial Sodium Channels (ENaC).

Israel Hanukoglu's Genealogy

Israel Hanukoglu's Publications (51)

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