Epernicus: Irene E Chiolo

Irene E Chiolo

Position:
Research Scientist

Genome Dynamics

Lawrence Berkeley National Laboratory (Berkeley, CA)
Degrees:
Past Advisors:

Gary H Karpen (as Post Doctoral Fellow)

Marco Foiani (as Post Doctoral Fellow)

Giordano Liberi (as Graduate Student - Ph.D.)
Research:
Other Experience:
2007 Summer Advanced Course in Drosophila Genetics and Genomics, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

2006 Visiting Postdoc in C. Boone Lab, Univ. of Toronto

2006 Visiting Postdoc in R.Rothstein lab, Columbia Univ.

Communities:

Irene Chiolo's Genealogy

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Irene Chiolo's Publications (8)

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair.
Chiolo I, Minoda A, Colmenares SU, Polyzos A, Costes SV, Karpen GH

Cell. 2011 Mar 4;144(5):732-44
HDACs link the DNA damage response, processing of double-strand breaks and autophagy.
Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein KA, Rothstein R, Botrugno OA, Parazzoli D, Oldani A, Minucci S, Foiani M

Nature. 2011 Mar 3;471(7336):74-9
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization.
Costes SV, Chiolo I, Pluth JM, Barcellos-Hoff MH, Jakob B

Mutation research. 2010 Apr-Jun;704(1-3):78-87
Role of homologous recombination in trabectedin-induced DNA damage.
Tavecchio M, Simone M, Erba E, Chiolo I, Liberi G, Foiani M, D'Incalci M, Damia G

European journal of cancer (Oxford, England : 1990). 2008 Mar;44(4):609-18
The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles.
Chiolo I, Saponaro M, Baryshnikova A, Kim JH, Seo YS, Liberi G

Molecular and cellular biology. 2007 Nov;27(21):7439-50
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation.
Chiolo I, Carotenuto W, Maffioletti G, Petrini JH, Foiani M, Liberi G

Molecular and cellular biology. 2005 Jul;25(13):5738-51
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase.
Liberi G, Maffioletti G, Lucca C, Chiolo I, Baryshnikova A, Cotta-Ramusino C, Lopes M, Pellicioli A, Haber JE, Foiani M

Genes & development. 2005 Feb 1;19(3):339-50
Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity.
Liberi G, Chiolo I, Pellicioli A, Lopes M, Plevani P, Muzi-Falconi M, Foiani M

The EMBO journal. 2000 Sep 15;19(18):5027-38

One Figure

hFbh1, the human homologue of yeast Srs2 DNA helicase, acts as a Janus Geminus with two identities: one faces Srs2 helicase activities and the other suppresses the requirement for postreplication repair (PRR) via its F-box domain (MCB,2007,27:7439)

Websites

Karpen lab

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