Epernicus: Howard A Shuman, Ph.D.

Howard A Shuman, Ph.D.

Positions:
Professor

Microbiology

Division of Biological Sciences

University of Chicago (Chicago, IL)

Director

Howard Taylor Ricketts Laboratory
Degrees:

Ph.D., Biological Chemistry, Harvard Medical School (Boston, MA)
Past Advisors:

Guido Guidotti (as Post Doctoral Fellow)

Jon Beckwith (as Graduate Student - Ph.D.)

Thomas G. Lessie (as Undergraduate Student)
Research:
We study the biology of Legionella pneumophila and its interactions with mammalian and protist hosts.
Other Experience:
1982-2010 Professor of Microbiology, Columbia University

Communities:

Howard Shuman's Genealogy

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Howard Shuman's Publications (23)

Loss of RNase R induces competence development in Legionella pneumophila.
Charpentier X, Faucher SP, Kalachikov S, Shuman HA

Journal of bacteriology. 2008 Dec;190(24):8126-36
Legionella eukaryotic-like type IV substrates interfere with organelle trafficking.
de Felipe KS, Glover RT, Charpentier X, Anderson OR, Reyes M, Pericone CD, Shuman HA

PLoS pathogens. 2008;4(8):e1000117
Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila.
Chen J, Reyes M, Clarke M, Shuman HA

Cellular microbiology. 2007 Jul;9(7):1660-71
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.
Shohdy N, Efe JA, Emr SD, Shuman HA

Proceedings of the National Academy of Sciences of the United States of America. 2005 Mar 29;102(13):4866-71
The amoebae plate test implicates a paralogue of lpxB in the interaction of Legionella pneumophila with Acanthamoeba castellanii.
Albers U, Reus K, Shuman HA, Hilbi H

Microbiology (Reading, England). 2005 Jan;151(Pt 1):167-82
The genomic sequence of the accidental pathogen Legionella pneumophila.
Chien M, Morozova I, Shi S, Sheng H, Chen J, Gomez SM, Asamani G, Hill K, Nuara J, Feder M, Rineer J, Greenberg JJ, Steshenko V, Park SH, Zhao B, Teplitskaya E, Edwards JR, Pampou S, Georghiou A, Chou IC, Iannuccilli W, Ulz ME, Kim DH, Geringer-Sameth A, Goldsberry C, Morozov P, Fischer SG, Segal G, Qu X, Rzhetsky A, Zhang P, Cayanis E, De Jong PJ, Ju J, Kalachikov S, Shuman HA, Russo JJ

Science (New York, N.Y.). 2004 Sep 24;305(5692):1966-8
Legionella effectors that promote nonlytic release from protozoa.
Chen J, de Felipe KS, Clarke M, Lu H, Anderson OR, Segal G, Shuman HA

Science (New York, N.Y.). 2004 Feb 27;303(5662):1358-61
Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum.
Otto GP, Wu MY, Clarke M, Lu H, Anderson OR, Hilbi H, Shuman HA, Kessin RH

Molecular microbiology. 2004 Jan;51(1):63-72
The art and design of genetic screens: Escherichia coli.
Shuman HA, Silhavy TJ

Nature reviews. Genetics. 2003 Jun;4(6):419-31
Just toothpicks and logic: how some labs succeed at solving complex problems.
Shuman HA

Journal of bacteriology. 2003 Jan;185(2):387-90
Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.
Hilbi H, Segal G, Shuman HA

Molecular microbiology. 2001 Nov;42(3):603-17
The detergent-soluble maltose transporter is activated by maltose binding protein and verapamil.
Reich-Slotky R, Panagiotidis C, Reyes M, Shuman HA

Journal of bacteriology. 2000 Feb;182(4):993-1000
Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila.
Segal G, Russo JJ, Shuman HA

Molecular microbiology. 1999 Nov;34(4):799-809
Possible origin of the Legionella pneumophila virulence genes and their relation to Coxiella burnetii.
Segal G, Shuman HA

Molecular microbiology. 1999 Aug;33(3):669-70
The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii.
Hales LM, Shuman HA

Journal of bacteriology. 1999 Aug;181(16):4879-89
Legionella pneumophila contains a type II general secretion pathway required for growth in amoebae as well as for secretion of the Msp protease.
Hales LM, Shuman HA

Infection and immunity. 1999 Jul;67(7):3662-6
Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages.
Segal G, Shuman HA

Infection and immunity. 1999 May;67(5):2117-24
Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila.
Wiater LA, Dunn K, Maxfield FR, Shuman HA

Infection and immunity. 1998 Sep;66(9):4450-60
Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome.
Segal G, Purcell M, Shuman HA

Proceedings of the National Academy of Sciences of the United States of America. 1998 Feb 17;95(4):1669-74
Mutations that alter the transmembrane signalling pathway in an ATP binding cassette (ABC) transporter.
Covitz KM, Panagiotidis CH, Hor LI, Reyes M, Treptow NA, Shuman HA

The EMBO journal. 1994 Apr 1;13(7):1752-9
Identification of Legionella pneumophila genes required for growth within and killing of human macrophages.
Sadosky AB, Wiater LA, Shuman HA

Infection and immunity. 1993 Dec;61(12):5361-73
Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages.
Marra A, Blander SJ, Horwitz MA, Shuman HA

Proceedings of the National Academy of Sciences of the United States of America. 1992 Oct 15;89(20):9607-11
Labeling of proteins with beta-galactosidase by gene fusion. Identification of a cytoplasmic membrane component of the Escherichia coli maltose transport system.
Shuman HA, Silhavy TJ, Beckwith JR

The Journal of biological chemistry. 1980 Jan 10;255(1):168-74

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Howard A Shuman, Ph.D.

Professor

Director

We study the biology of Legionella pneumophila and its interactions with mammalian and protist hosts.

Howard Shuman's Genealogy

Howard Shuman's Publications (23)