Epernicus: Hashem A Dbouk, M.Sc.

Hashem A Dbouk, M.Sc.

Position:
Graduate Student - Ph.D.

Molecular Pharmacology

Albert Einstein College of Medicine (Bronx, New York)
Advisor:
Jonathan Backer
Degrees:

M.Sc., Molecular Pharmacology, Albert Einstein College of Medicine (Bronx, New York)

M.Sc., Biology, American University of Beirut (Beirut, Lebanon)

B.S., Biology, Lebanese University (Beirut, Lebanon)
Past Advisors:

Rabih S Talhouk (as Graduate Student - Masters)

Marwan E. El-Sabban (as Graduate Student - Masters)

Ali Bazarbachi (as Visiting Student)

Raghida Abou-Merhi (as Undergraduate Student)
Research:
Regulation of Class IA PI3-kinases

The regulation of p110beta by p85 and Gbetagamma subunits and their differential contribution to signaling.
Other Experience:
2001-2007 Green Peace

Communities:

Hashem Dbouk's Genealogy

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Hashem Dbouk's Publications (7)

A beta version of life: p110β takes center stage.
Dbouk HA, Backer JM

Oncotarget. 2010 Dec;1(8):729-33
A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.
Dbouk HA, Pang H, Fiser A, Backer JM

Proceedings of the National Academy of Sciences of the United States of America. 2010 Nov 16;107(46):19897-902
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.
Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S

Cancer cell. 2009 Dec 8;16(6):463-74
Connexins: a myriad of functions extending beyond assembly of gap junction channels.
Dbouk HA, Mroue RM, El-Sabban ME, Talhouk RS

Cell communication and signaling : CCS. 2009;7:4
An overview of familial Mediterranean fever with emphasis on pyrin and colchicine.
Dbouk HA, Uthman IW

Le Journal médical libanais. The Lebanese medical journal. 2008 Jan-Mar;56(1):35-41
PS-341 or a combination of arsenic trioxide and interferon-alpha inhibit growth and induce caspase-dependent apoptosis in KSHV/HHV-8-infected primary effusion lymphoma cells.
Abou-Merhi R, Khoriaty R, Arnoult D, El Hajj H, Dbouk H, Munier S, El-Sabban ME, Hermine O, Gessain A, de Thé H, Mahieux R, Bazarbachi A

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2007 Aug;21(8):1792-801
Significance of CEA and VEGF as Diagnostic Markers of Colorectal Cancer in Lebanese Patients.
Dbouk HA, Tawil A, Nasr F, Kandakarjian L, Abou-Merhi R

Open clinical cancer journal. 2007;1:1-5

Hashem Dbouk's Posters and Presentations (4)

Gβγ-mediated activation of p110β is required for transformation (poster)
Hashem A Dbouk, Bernd Nurnberg, T Kendall Harden, & Jonathan M. Backer

Gordon Conference - Mechanisms of Cell Siganling; 08/2011
Disruption of an inhibitory interface with p85 is responsible for the oncogenic potential of p110β (poster)
Hashem A Dbouk, Jonathan M Backer

PTEN Pathways and Targets, Cold Spring Harbor Labs, NY; 03/2010
Connexin43 over-expression reduces proliferation and invasiveness of MCF-7 cells (poster)
Hashem A Dbouk, Antoine A Khalil, Marwan E El-Sabban, Rabih S Talhouk

the AACR conference “Advances in Cancer Research: From the Laboratory to the Clinic”, Dead Sea, Jordan; 03/2008
Functional Hetero-cellular Gap Junctional Complexes Induce Mammary Epithelial Cell Differentiation (poster)
Talhouk, RS, Mroue, R, Mokalled, M, Abi-Mosleh, L, Nehme, R, Ismail, A, Zaatari, M, Dbouk, HA, and El-Sabban, ME

Gordon Conference on Cell Contact and Adhesion, il-Ciocco, Italy; 05/2007

One Figure

Cx43 transfected cells

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