Epernicus: Guilian M Xu, Ph.D.

Guilian M Xu, Ph.D.

Position:
Assistant Research Scientist

Neuroscience

University of Florida College of Medicine (Gainesville, FL)
Advisor:
David R. Borchelt
Degrees:

Ph.D., Physiology and Neuropathology, The University of Hong Kong (Pokfulam, Hong Kong)

B.Sc., Biochemistry, Sichuan University (Chengdu, China)
Past Advisors:

George Uhl (as Senior Scientist)

David R. Borchelt (as Post Doctoral Fellow)

David R. Borchelt (as Visiting Student)

Fai Tang (as Graduate Student - Ph.D.)
Research:
Transgenic mouse models on neurodegenerative diseases.
Other Experience:
1991-1996 Analytical Chemist in China Railway No.2 Engineering Group Co., Ltd.

Communities:

Guilian Xu's Genealogy

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Guilian Xu's Publications (21)

Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1.
Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, Whitelegge JP

The Journal of biological chemistry. 2008 Mar 28;283(13):8340-50
Amyloid precursor protein increases cortical neuron size in transgenic mice.
Oh ES, Savonenko AV, King JF, Fangmark Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC

Neurobiology of aging. 2008 Feb 25
Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice.
Xu G, Karch C, Li N, Lin N, Fromholt D, Gonzales V, Borchelt DR

PLoS ONE. 2008;3(9):e3159
Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis.
Verret L, Jankowsky JL, Xu GM, Borchelt DR, Rampon C

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Jun 20;27(25):6771-80
Mapping superoxide dismutase 1 domains of non-native interaction: roles of intra- and intermolecular disulfide bonding in aggregation.
Wang J, Xu G, Borchelt DR

Journal of neurochemistry. 2006 Mar;96(5):1277-88
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.
Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Dec 14;25(50):11693-709
Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA.
Wang J, Xu G, Slunt HH, Gonzales V, Coonfield M, Fromholt D, Copeland NG, Jenkins NA, Borchelt DR

Neurobiology of disease. 2005 Dec;20(3):943-52
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation.
Wang J, Xu G, Li H, Gonzales V, Fromholt D, Karch C, Copeland NG, Jenkins NA, Borchelt DR

Human molecular genetics. 2005 Aug 15;14(16):2335-47
Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease.
Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 May 25;25(21):5217-24
Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities.
Savonenko A, Xu GM, Melnikova T, Morton JL, Gonzales V, Wong MP, Price DL, Tang F, Markowska AL, Borchelt DR

Neurobiology of disease. 2005 Apr;18(3):602-17
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR

Human molecular genetics. 2004 Jan 15;13(2):159-70
Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
Jankowsky JL, Xu G, Fromholt D, Gonzales V, Borchelt DR

Journal of neuropathology and experimental neurology. 2003 Dec;62(12):1220-7
Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice.
Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE

Neurobiology of disease. 2003 Oct;14(1):133-45
Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE.
Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL

Neurobiology of disease. 2003 Apr;12(3):194-211
Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.
Jankowsky JL, Savonenko A, Schilling G, Wang J, Xu G, Borchelt DR

Current neurology and neuroscience reports. 2002 Sep;2(5):457-64
Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site.
Wang J, Xu G, Gonzales V, Coonfield M, Fromholt D, Copeland NG, Jenkins NA, Borchelt DR

Neurobiology of disease. 2002 Jul;10(2):128-38
High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation.
Wang J, Xu G, Borchelt DR

Neurobiology of disease. 2002 Mar;9(2):139-48
Abeta deposition does not cause the aggregation of endogenous tau in transgenic mice.
Xu G, Gonzales V, Borchelt DR

Alzheimer disease and associated disorders. 2002 Jul-Sep;16(3):196-201
Rapid detection of protein aggregates in the brains of Alzheimer patients and transgenic mouse models of amyloidosis.
Xu G, Gonzales V, Borchelt DR

Alzheimer disease and associated disorders. 2002 Jul-Sep;16(3):191-5
Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.
Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR

Human molecular genetics. 2001 Oct 15;10(22):2525-37
Transgenic mouse and chemical lesion approaches to the study of Alzheimer's disease.
Tang F, Li H, Nag S, Xu G, Chan T

Chinese medical journal. 1997 Aug;110(8):642-7

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Guilian M Xu, Ph.D.

Assistant Research Scientist

Transgenic mouse models on neurodegenerative diseases.

Guilian Xu's Genealogy

Guilian Xu's Publications (21)