Epernicus: Gary M Deyter, Ph.D.

Gary M Deyter, Ph.D.

Position:
Post Doctoral Fellow

Basic Sciences

Fred Hutchinson Cancer Research Center (Seattle, WA)
Degrees:

Ph.D., Genes and Development, University of Texas M. D. Anderson Cancer Center (Houston, TX)

B.A., Biology, Rutgers University (New Brunswick, NJ)
Past Advisors:

Jill M Schumacher (as Graduate Student - Ph.D.)

Bonnie Firestein (as Technician)
Research:
Elucidation of the role histone and microtubule post-translational modifications play in chromosome segregation

My primary research interest is to determine how kinetochore structure and function are influenced by post-translational modifications (PTMs). The kinetochore is a crucial organelle devoted to chromosome segregation, and PTMs (particularly phosphorylation) influence the function of key mitotic proteins. My research will focus on discovering kinetochore phosphorylation and methylation events, especially those that are enriched at the chromatin foundation of the kinetochore- the centromere. Additionally, microtubules are subject to a variety of PTMs, and research predominantly with neuronal systems hints at the existence of a microtubule-based PTM code similar to the histone code. I will employ genetic and biochemical techniques with S. cerevisiae to "read" centromeric histone and mitotic microtubule PTMs, determine the physiological consequences of the PTMs, and begin to decipher their codes.

Communities:

Gary Deyter's Genealogy

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Gary Deyter's Publications (7)

Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo.
Riefler GM, Dent SY, Schumacher JM

The Journal of biological chemistry. 2008 May 9;283(19):12763-8
A novel role for snapin in dendrite patterning: interaction with cypin.
Chen M, Lucas KG, Akum BF, Balasingam G, Stawicki TM, Provost JM, Riefler GM, Jörnsten RJ, Firestein BL

Molecular biology of the cell. 2005 Nov;16(11):5103-14
The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation.
Zhang K, Lin W, Latham JA, Riefler GM, Schumacher JM, Chan C, Tatchell K, Hawke DH, Kobayashi R, Dent SY

Cell. 2005 Sep 9;122(5):723-34
The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.
Han Z, Riefler GM, Saam JR, Mango SE, Schumacher JM

Current biology : CB. 2005 May 24;15(10):894-904
Cypin regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly.
Akum BF, Chen M, Gunderson SI, Riefler GM, Scerri-Hansen MM, Firestein BL

Nature neuroscience. 2004 Feb;7(2):145-52
Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor).
Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL

The Biochemical journal. 2003 Jul 1;373(Pt 1):49-55
Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS.
Riefler GM, Firestein BL

The Journal of biological chemistry. 2001 Dec 21;276(51):48262-8

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Gary M Deyter, Ph.D.

Post Doctoral Fellow

Elucidation of the role histone and microtubule post-translational modifications play in chromosome segregation

Gary Deyter's Genealogy

Gary Deyter's Publications (7)