Gopal Das, Ph.D.
- Positions:
Associate Professor
Department of Entomology
Bangladesh Agricultural University, Mymensingh, Bangladesh
JSPS Post-doctoral fellow
Department of Information Biology
Tohoku University, Sendai, Japan
- Advisor:
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Degrees:
Ph.D., in Information Biology, Tohoku University (Sendai, Japan)M.S., in Information Biology, Tohoku University (Sendai, Japan)M.S., in Entomology, Bangladesh Agricultural University, Mymensingh, BangladeshB.Sc., Ag. (Bachelor of Science in Agriculture), Bangladesh Agricultural University, Mymensingh, Bangladesh
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Past Advisors:
Prof Khandakar Shariful Islam (as Graduate Student - Masters)
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Research:
Regulatory Roles of FosB/DeltaFosB Transcription Factor in the Neuroendocrine Neurons
My research focus mainly on the elucidation of physiological role of FosB/deltaFosB transcription factor in relationship to the HPA-stress axis. FosB is a Fos family transcription factor under Immediate Early Genes (IEG). The fosB-gene produces two different proteins by alternative splicing, FosB and its stable isform delta FosB. FosB persist in the stimulated cell for a short peroid but deltaFosB exists for a long peroid, hour to even months. I previuosly reported that (J of Neuroendocrinology) FosB is regulated by circulating glucocorticoid (GC) and interestingly circulating GC is not enough to stimulate FosB gene, once FosB is stimulated by surgical stress then surgery induced FosB expression was potentiated by circulating GC. In vitro study also showed that Forskolin (a stimulant) significantly stimulated FosB-gene promoter activity in the hypothalamic 4B cells and Fsk-stimulated induction was significantly suppressed by Dexamethasone ( a synthetic GC). FosB predominanatly induced in the hypothalamic CRH and AVP neurons. Therefore it was hypothesized that indiced FosB/deltaFosB might play role in CRH or AVP gene expression in absence of GC. Currently I have taken the following projects to make the clear physiological role of FosB/deltaFosB in the neuroendocrine neurons; (1) Role of FosB/deltaFosB in neuroendocrine responses to stress using FosB (-/-) knockout mice (2) Inhibition of FosB-gene by local injrctions of siRNA probes for evaluating the roles of FosB/deltaFosB in stress responses. (3) In vitro investigations of regulatory functions of FosB/deltaFosB in the paPVN CRH and SON AVP neurons using hypothalamic 4B cell lines (4) possibility of interaction between GR with FosB promoter (4) Nature of FosB/deltaFosB expression in the hypothalamus using different stressors
Gopal Das's Genealogy
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