Assistant Professor

INSERM U768, Développement normal et pathologique du système immunitaire

Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine,

INSERM - Univerité Paris Descartes

Me and my team are studying at the genetic, molecular and cellular levels the development, homeostasis and interaction of T cells and dendritic cells in normal and pathologic conditions

I am leading a research team in France in the Inserm Department U768 “normal and pathologic development of the immune system”. The aim of my project is to characterize new genes and isoforms involved in the development, homeostasis, phenotype and functions of two major populations of the immune system: regulatory T cells that maintain self-tolerance, control auto- immune diseases and modulate the intensity of immune responses against foreign antigens; and dendritic cells, the immune sentinels of the organism that process and present foreign antigens to initiate and regulate immune responses. I try to understand the molecular basis of their differentiation, homeostasis and their complex interactions in inflammation, autoimmune disease, cancers, and in immune deficits in mice and humans, with the final aim to develop biomedical treatments based on these findings.