Epernicus: Frederic D Sigoillot, Ph.D.

Frederic D Sigoillot, Ph.D.

Position:
Post Doctoral Fellow

Cell Biology

Harvard Medical School (Boston, MA)
Advisor:
Randy King
Degrees:

Ph.D., Biochemistry and Molecular Biology, Wayne State University - School of Medicine (Detroit, MI)
Past Advisors:

Hedeel I Guy-Evans (as Graduate Student - Ph.D.)
Research:

Communities:

Frederic Sigoillot's Genealogy

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Frederic Sigoillot's Publications (11)

A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens.
Sigoillot FD, Lyman S, Huckins JF, Adamson B, Chung E, Quattrochi B, King RW

Nature methods. 2012 Feb 19
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ

Nature cell biology. 2012;14(3):318-28
Vigilance and validation: Keys to success in RNAi screening.
Sigoillot FD, King RW

ACS chemical biology. 2011 Jan 21;6(1):47-60
A time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse movies.
Sigoillot FD, Huckins JF, Li F, Zhou X, Wong ST, King RW

PloS one. 2011;6(9):e25511
Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade.
Kotsis DH, Masko EM, Sigoillot FD, Di Gregorio R, Guy-Evans HI, Evans DR

Molecular and cellular biochemistry. 2007 Jul;301(1-2):69-81
Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase.
Sigoillot FD, Kotsis DH, Masko EM, Bame M, Evans DR, Evans HI

Frontiers in bioscience : a journal and virtual library. 2007;12:3892-8
Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD.
Sigoillot FD, Kotsis DH, Serre V, Sigoillot SM, Evans DR, Guy HI

The Journal of biological chemistry. 2005 Jul 8;280(27):25611-20
Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells.
Sigoillot FD, Sigoillot SM, Guy HI

International journal of cancer. Journal international du cancer. 2004 Apr 20;109(4):491-8
Cell cycle-dependent regulation of pyrimidine biosynthesis.
Sigoillot FD, Berkowski JA, Sigoillot SM, Kotsis DH, Guy HI

The Journal of biological chemistry. 2003 Jan 31;278(5):3403-9
Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.
Sigoillot FD, Evans DR, Guy HI

The Journal of biological chemistry. 2002 Jul 5;277(27):24809-17
Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades.
Sigoillot FD, Evans DR, Guy HI

The Journal of biological chemistry. 2002 May 3;277(18):15745-51

One Figure

HeLa cells (examples of binucleation).
DNA staining in green(Hoescht 33342)
Actin staining in red (TRITC-phalloidin)

Websites

King Lab

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