Epernicus: Eric J Vallender, Ph.D.

Eric J Vallender, Ph.D.

Position:
Post Doctoral Fellow

New England Primate Research Center

Harvard Medical School (Boston, MA)
Advisor:
Gregory M. Miller
Degrees:

Ph.D., Genetics, University of Chicago (Chicago, IL)

B.A., Anthropology, University of Illinois at Urbana-Champaign (Urbana, IL)

B.Sc., Biochemistry, University of Illinois at Urbana-Champaign (Urbana, IL)
Past Advisors:

Bruce T. Lahn (as Graduate Student - Ph.D.)

Yi Lu (as Undergraduate Student)
Research:

Communities:

Eric Vallender's Genealogy

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Eric Vallender's Publications (31)

Genetic basis of human brain evolution.
Vallender EJ, Mekel-Bobrov N, Lahn BT

Trends in neurosciences. 2008 Dec;31(12):637-44
Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association.
Xie Z, Vallender EJ, Yu N, Kirstein SL, Yang H, Bahn ME, Westmoreland SV, Miller GM

Journal of neuroscience research. 2008 Nov 15;86(15):3435-46
Functional variation in the 3' untranslated region of the serotonin transporter in human and rhesus macaque.
Vallender EJ, Priddy CM, Hakim S, Yang H, Chen GL, Miller GM

Genes, brain, and behavior. 2008 Aug;7(6):690-7
Human Expression Variation in the Mu-Opioid Receptor is Paralleled in Rhesus Macaque.
Vallender EJ, Priddy CM, Chen GL, Miller GM

Behavior genetics. 2008 Jul;38(4):390-5
Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques.
Vallender EJ, Lynch L, Novak MA, Miller GM

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2008 Jul 24
Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies.
Lee AS, Gutiérrez-Arcelus M, Perry GH, Vallender EJ, Johnson WE, Miller GM, Korbel JO, Lee C

Human molecular genetics. 2008 Apr 15;17(8):1127-36
Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host.
Xiang AP, Mao FF, Li WQ, Park D, Ma BF, Wang T, Vallender TW, Vallender EJ, Zhang L, Lee J, Waters JA, Zhang XM, Yu XB, Li SN, Lahn BT

Human molecular genetics. 2008 Jan 1;17(1):27-37
Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro.
Chen GL, Vallender EJ, Miller GM

Human genetics. 2008 Jan;122(6):645-57
Exploring the origins of the human brain through molecular evolution.
Vallender EJ

Brain, behavior and evolution. 2008;72(2):168-77
Evolutionary and biomedical insights from the rhesus macaque genome.
Gibbs RA, Rogers J, Katze MG, Bumgarner R, Weinstock GM, Mardis ER, Remington KA, Strausberg RL, Venter JC, Wilson RK, Batzer MA, Bustamante CD, Eichler EE, Hahn MW, Hardison RC, Makova KD, Miller W, Milosavljevic A, Palermo RE, Siepel A, Sikela JM, Attaway T, Bell S, Bernard KE, Buhay CJ, Chandrabose MN, Dao M, Davis C, Delehaunty KD, Ding Y, Dinh HH, Dugan-Rocha S, Fulton LA, Gabisi RA, Garner TT, Godfrey J, Hawes AC, Hernandez J, Hines S, Holder M, Hume J, Jhangiani SN, Joshi V, Khan ZM, Kirkness EF, Cree A, Fowler RG, Lee S, Lewis LR, Li Z, Liu YS, Moore SM, Muzny D, Nazareth LV, Ngo DN, Okwuonu GO, Pai G, Parker D, Paul HA, Pfannkoch C, Pohl CS, Rogers YH, Ruiz SJ, Sabo A, Santibanez J, Schneider BW, Smith SM, Sodergren E, Svatek AF, Utterback TR, Vattathil S, Warren W, White CS, Chinwalla AT, Feng Y, Halpern AL, Hillier LW, Huang X, Minx P, Nelson JO, Pepin KH, Qin X, Sutton GG, Venter E, Walenz BP, Wallis JW, Worley KC, Yang SP, Jones SM, Marra MA, Rocchi M, Schein JE, Baertsch R, Clarke L, Csürös M, Glasscock J, Harris RA, Havlak P, Jackson AR, Jiang H, Liu Y, Messina DN, Shen Y, Song HX, Wylie T, Zhang L, Birney E, Han K, Konkel MK, Lee J, Smit AF, Ullmer B, Wang H, Xing J, Burhans R, Cheng Z, Karro JE, Ma J, Raney B, She X, Cox MJ, Demuth JP, Dumas LJ, Han SG, Hopkins J, Karimpour-Fard A, Kim YH, Pollack JR, Vinar T, Addo-Quaye C, Degenhardt J, Denby A, Hubisz MJ, Indap A, Kosiol C, Lahn BT, Lawson HA, Marklein A, Nielsen R, Vallender EJ, Clark AG, Ferguson B, Hernandez RD, Hirani K, Kehrer-Sawatzki H, Kolb J, Patil S, Pu LL, Ren Y, Smith DG, Wheeler DA, Schenck I, Ball EV, Chen R, Cooper DN, Giardine B, Hsu F, Kent WJ, Lesk A, Nelson DL, O'brien WE, Prüfer K, Stenson PD, Wallace JC, Ke H, Liu XM, Wang P, Xiang AP, Yang F, Barber GP, Haussler D, Karolchik D, Kern AD, Kuhn RM, Smith KE, Zwieg AS

Science (New York, N.Y.). 2007 Apr 13;316(5822):222-34
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro.
Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM

The Journal of pharmacology and experimental therapeutics. 2007 Apr;321(1):116-27
Uncovering the mutation-fixation correlation in short lineages.
Vallender EJ, Lahn BT

BMC evolutionary biology. 2007;7:168
Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage.
Evans PD, Mekel-Bobrov N, Vallender EJ, Hudson RR, Lahn BT

Proceedings of the National Academy of Sciences of the United States of America. 2006 Nov 28;103(48):18178-83
Multiple independent origins of sex chromosomes in amniotes.
Vallender EJ, Lahn BT

Proceedings of the National Academy of Sciences of the United States of America. 2006 Nov 28;103(48):18031-2
SPEED: a molecular-evolution-based database of mammalian orthologous groups.
Vallender EJ, Paschall JE, Malcom CM, Lahn BT, Wyckoff GJ

Bioinformatics (Oxford, England). 2006 Nov 15;22(22):2835-7
Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomes.
Choi SS, Vallender EJ, Lahn BT

Molecular biology and evolution. 2006 Nov;23(11):2131-3
A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway.
Vallender EJ, Lahn BT

Human molecular genetics. 2006 Oct 15;15(20):3034-40
Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates.
Dorus S, Anderson JR, Vallender EJ, Gilbert SL, Zhang L, Chemnick LG, Ryder OA, Li W, Lahn BT

Human molecular genetics. 2006 Jul 1;15(13):2031-7
Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ.
Evans PD, Vallender EJ, Lahn BT

Gene. 2006 Jun 21;375:75-9
Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.
Evans PD, Gilbert SL, Mekel-Bobrov N, Vallender EJ, Anderson JR, Vaez-Azizi LM, Tishkoff SA, Hudson RR, Lahn BT

Science (New York, N.Y.). 2005 Sep 9;309(5741):1717-20
Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.
Mekel-Bobrov N, Gilbert SL, Evans PD, Vallender EJ, Anderson JR, Hudson RR, Tishkoff SA, Lahn BT

Science (New York, N.Y.). 2005 Sep 9;309(5741):1720-2
A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate.
Wyckoff GJ, Malcom CM, Vallender EJ, Lahn BT

Trends in genetics : TIG. 2005 Jul;21(7):381-5
The X chromosome: not just her brother's keeper.
Vallender EJ, Pearson NM, Lahn BT

Nature genetics. 2005 Apr;37(4):343-5
Accelerated evolution of nervous system genes in the origin of Homo sapiens.
Dorus S, Vallender EJ, Evans PD, Anderson JR, Gilbert SL, Mahowald M, Wyckoff GJ, Malcom CM, Lahn BT

Cell. 2004 Dec 29;119(7):1027-40
Effects of chromosomal rearrangements on human-chimpanzee molecular evolution.
Vallender EJ, Lahn BT

Genomics. 2004 Oct;84(4):757-61

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Eric J Vallender, Ph.D.

Post Doctoral Fellow

Eric Vallender's Genealogy

Eric Vallender's Publications (31)