Epernicus: Erin F Simonds, B.S.

Erin F Simonds, B.S.

(Ph.D. in progress)

Position:
Graduate Student - Ph.D.

Microbiology and Immunology

Stanford University School of Medicine (Stanford, CA)
Advisor:
Garry P Nolan
Degrees:

Ph.D. (in progress), Microbiology and Immunology, Stanford University School of Medicine (Stanford, CA)

B.S., Molecular and Cell Biology, University of Connecticut (Storrs, CT)
Past Advisors:

Michael R Knowles (as Technician)

David J Goldhamer (as Undergraduate Student)
Research:
My primary research interest is the relationship between cell signaling, drug resistance, and clinical outcome in leukemia. Specifically, my thesis research involves developing next-generation flow cytometry methods to examine cytokine signaling in the healthy immune system, and the redirection of normal signaling pathways in childhood leukemia. By measuring protein signaling at the single-cell level, we obtain detailed biochemical profiles of rare and complex samples. Using computational methods, hidden relationships and predictive network models can be mined directly from this multiparameter signaling data.

Bulk genomic and proteomic assays overlook the clonal heterogeneity of cancer. By combining phospho-specific flow cytometry and microarray technologies, we hope to unravel the signaling behaviors associated with poor outcome in childhood leukemia.
Honors:
2010 Travel Award (International Congress of Immunology, Kobe, Japan)

2004 New England Scholar (University of Connecticut)

2001 Eagle Scout (Boy Scouts of America)

Communities:

Erin Simonds's Genealogy

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Erin Simonds's Publications (7)

Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum.
Bendall SC, Simonds EF, Qiu P, Amir el-AD, Krutzik PO, Finck R, Bruggner RV, Melamed R, Trejo A, Ornatsky OI, Balderas RS, Plevritis SK, Sachs K, Pe'er D, Tanner SD, Nolan GP

Science (New York, N.Y.). 2011 May 6;332(6030):687-96
Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE.
Qiu P, Simonds EF, Bendall SC, Gibbs KD, Bruggner RV, Linderman MD, Sachs K, Nolan GP, Plevritis SK

Nature biotechnology. 2011;29(10):886-91
Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses.
O'Gorman WE, Sampath P, Simonds EF, Sikorski R, O'Malley M, Krutzik PO, Chen H, Panchanathan V, Chaudhri G, Karupiah G, Lewis DB, Thorne SH, Nolan GP

Cell host & microbe. 2010 Aug 19;8(2):174-85
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms.
Oh ST, Simonds EF, Jones C, Hale MB, Goltsev Y, Gibbs KD, Merker JD, Zehnder JL, Nolan GP, Gotlib J

Blood. 2010 Aug 12;116(6):988-92
Speeding the flow toward personalized therapy in childhood acute leukemia.
Simonds EF, Davis KL, Lacayo NJ

Pediatric blood & cancer. 2009 Oct;53(4):525-6
The initial phase of an immune response functions to activate regulatory T cells.
O'Gorman WE, Dooms H, Thorne SH, Kuswanto WF, Simonds EF, Krutzik PO, Nolan GP, Abbas AK

Journal of immunology (Baltimore, Md. : 1950). 2009 Jul 1;183(1):332-9
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML

Cancer cell. 2008 Oct 7;14(4):335-43

Erin Simonds's Posters and Presentations (5)

Signaling and immunophenotypic diversity in pediatric acute myeloid leukemia as defined by 31-parameter single-cell mass cytometry (poster)
Erin F. Simonds, Sean C. Bendall, Kara L. Davis, Harris G. Fienberg, Rachel L. Finck, El-ad D. Amir, Ina Radtke, Dana Pe’er, Garry P. Nolan

ASH (American Society of Hematology) Annual Meeting, San Diego, CA; 12/2011
A single-cell view of the signaling landscape in human bone marrow obtained by 31-parameter mass cytometry (presentation)
Erin F Simonds, Sean C Bendall, Michael D Linderman, Peng Qiu, Zachary B Bjornson, El-ad D Amir, Rachel Finck, Robert V Bruggner, Sylvia K Plevritis, Garry P Nolan

CSHL Systems Biology: Networks, Cold Spring Harbor, NY, USA; 03/2011
Immunophenotypic diversity in acute myeloid leukemia as defined by 31-parameter single-cell mass cytometry (presentation)
Erin F Simonds, Sean C Bendall, Michael D Linderman, Peng Qiu, Zachary B Bjornson, El-ad D Amir, Rachel Finck, Sylvia K Plevritis, Dana Pe’er, Garry P Nolan

AACR Stem Cells, Development, and Cancer, Vancouver, BC, Canada; 03/2011
Next-generation 31-parameter flow cytometry reveals systems-level relationships in human bone marrow signaling and homeostasis (presentation)
Erin F Simonds, Sean C Bendall, Olga Ornatsky, Dmitry Bandura, Vladimir Baranov, Scott D Tanner, Robert S Balderas, Garry P Nolan

14th International Congress of Immunology, Kobe, Japan; 08/2010
Paired phospho-proteomic and genomic analyses reveal functionally distinct subclones in refractory pediatric acute myeloid leukemia (poster)
Erin F Simonds, Joshua D Schiffman, M Monica Gramatges, Gary VH Dahl, James M Ford, Norman J Lacayo, Hanlee Ji, Garry P Nolan

AACR (American Association for Cancer Research) Annual Meeting, Denver, CO; 04/2009

One Figure

In a next-generation form of flow cytometry -- mass cytometry -- antibodies are tagged with rare heavy metal isotopes instead of fluorescent dyes. These antibodies are used to detect coordinated fluctuations in phosphoproteins in response to stimuli.

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