Epernicus: Eric B Fauman, Ph.D.

Eric B Fauman, Ph.D.

Position:
Associate Research Fellow

Computational Sciences CoE

Pfizer, Inc. (New York, NY)
Degrees:

Ph.D., Biochemistry & Biophysics, University of California, San Francisco (San Francisco, CA)

B.S., Cellular and Molecular Biology, University of Michigan College of Literature, Science, and the Arts (Ann Arbor, MI)
Past Advisors:

Mark A. Saper (as Post Doctoral Fellow)

Robert M Stroud (as Graduate Student - Ph.D.)
Research:
Honors:
1986 Phi Beta Kappa

Communities:

Eric Fauman's Genealogy

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Eric Fauman's Publications (22)

Structure-based druggability assessment--identifying suitable targets for small molecule therapeutics.
Fauman EB, Rai BK, Huang ES

Current opinion in chemical biology. 2011 Aug;15(4):463-8
Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
Evdokimov AG, Mekel M, Hutchings K, Narasimhan L, Holler T, McGrath T, Beattie B, Fauman E, Yan C, Heaslet H, Walter R, Finzel B, Ohren J, McConnell P, Braden T, Sun F, Spessard C, Banotai C, Al-Kassim L, Ma W, Wengender P, Kole D, Garceau N, Toogood P, Liu J

Journal of structural biology. 2008 Apr;162(1):152-69
Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.
Taylor CP, Angelotti T, Fauman E

Epilepsy research. 2007 Feb;73(2):137-50
Structural bioinformatics in drug discovery.
Fauman EB, Hopkins AL, Groom CR

Methods of biochemical analysis. 2003;44:477-97
Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352.
Delaney AM, Printen JA, Chen H, Fauman EB, Dudley DT

Molecular and cellular biology. 2002 Nov;22(21):7593-602
RNA methylation under heat shock control.
Bügl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U

Molecular cell. 2000 Aug;6(2):349-60
Analysis of a mutation in phosphodiesterase type 4 that alters both inhibitor activity and nucleotide selectivity.
Herman SB, Juilfs DM, Fauman EB, Juneau P, Menetski JP

Molecular pharmacology. 2000 May;57(5):991-9
Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.
Fauman EB, Cogswell JP, Lovejoy B, Rocque WJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ, Saper MA

Cell. 1998 May 15;93(4):617-25
Structure and function of the protein tyrosine phosphatases.
Fauman EB, Saper MA

Trends in biochemical sciences. 1996 Nov;21(11):413-7
The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.
Fauman EB, Yuvaniyama C, Schubert HL, Stuckey JA, Saper MA

The Journal of biological chemistry. 1996 Aug 2;271(31):18780-8
Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM

Protein engineering. 1996 Jan;9(1):69-75
Significance of structural changes in proteins: expected errors in refined protein structures.
Stroud RM, Fauman EB

Protein science : a publication of the Protein Society. 1995 Nov;4(11):2392-404
A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.
Schubert HL, Fauman EB, Stuckey JA, Dixon JE, Saper MA

Protein science : a publication of the Protein Society. 1995 Sep;4(9):1904-13
The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.
Zhang ZY, Wang Y, Wu L, Fauman EB, Stuckey JA, Schubert HL, Saper MA, Dixon JE

Biochemistry. 1994 Dec 27;33(51):15266-70
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate.
Stuckey JA, Schubert HL, Fauman EB, Zhang ZY, Dixon JE, Saper MA

Nature. 1994 Aug 18;370(6490):571-5
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.
Fauman EB, Rutenber EE, Maley GF, Maley F, Stroud RM

Biochemistry. 1994 Feb 15;33(6):1502-11
Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM

Journal of molecular biology. 1993 Aug 20;232(4):1101-16
Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design.
Rutenber E, Fauman EB, Keenan RJ, Fong S, Furth PS, Ortiz de Montellano PR, Meng E, Kuntz ID, DeCamp DL, Salto R

The Journal of biological chemistry. 1993 Jul 25;268(21):15343-6
Tracking conformational states in allosteric transitions of phosphorylase.
Browner MF, Fauman EB, Fletterick RJ

Biochemistry. 1992 Nov 24;31(46):11297-304
1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.
Earnest T, Fauman E, Craik CS, Stroud R

Proteins. 1991;10(3):171-87
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Montfort WR, Perry KM, Fauman EB, Finer-Moore JS, Maley GF, Hardy L, Maley F, Stroud RM

Biochemistry. 1990 Jul 31;29(30):6964-77
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
Perry KM, Fauman EB, Finer-Moore JS, Montfort WR, Maley GF, Maley F, Stroud RM

Proteins. 1990;8(4):315-33

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Eric B Fauman, Ph.D.

Associate Research Fellow

Eric Fauman's Genealogy

Eric Fauman's Publications (22)