Epernicus: Dennis W Wolan, Ph.D.

Dennis W Wolan, Ph.D.

Position:
Assistant Professor

Molecular and Experimental Medicine

Chemical Physiology

The Scripps Research Institute (La Jolla, CA)
Degrees:

Ph.D., Structural Biology, The Scripps Research Institute (La Jolla, CA)
Past Advisors:

James A Wells (as Post Doctoral Fellow)

Ian A. Wilson (as Graduate Student - Ph.D.)

Dennis Stuehr (as Technician)
Research:

Communities:

Dennis Wolan's Genealogy

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Dennis Wolan's Publications (10)

Small-molecule activators of a proenzyme.
Wolan DW, Zorn JA, Gray DC, Wells JA

Science (New York, N.Y.). 2009 Nov 6;326(5954):853-8
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
Li C, Xu L, Wolan DW, Wilson IA, Olson AJ

Journal of medicinal chemistry. 2004 Dec 30;47(27):6681-90
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.
Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA

The Journal of biological chemistry. 2004 Apr 23;279(17):18034-45
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.
Wolan DW, Cheong CG, Greasley SE, Wilson IA

Biochemistry. 2004 Feb 10;43(5):1171-83
Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA

Biochemistry. 2003 Sep 23;42(37):10904-14
Structural insights into the avian AICAR transformylase mechanism.
Wolan DW, Greasley SE, Beardsley GP, Wilson IA

Biochemistry. 2002 Dec 31;41(52):15505-13
Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.
Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA

Nature immunology. 2001 Mar;2(3):248-54
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.
Ghosh S, Wolan D, Adak S, Crane BR, Kwon NS, Tainer JA, Getzoff ED, Stuehr DJ

The Journal of biological chemistry. 1999 Aug 20;274(34):24100-12
Antifungal imidazoles block assembly of inducible NO synthase into an active dimer.
Sennequier N, Wolan D, Stuehr DJ

The Journal of biological chemistry. 1999 Jan 8;274(2):930-8
Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.
Siddhanta U, Presta A, Fan B, Wolan D, Rousseau DL, Stuehr DJ

The Journal of biological chemistry. 1998 Jul 24;273(30):18950-8

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Dennis W Wolan, Ph.D.

Assistant Professor

Dennis Wolan's Genealogy

Dennis Wolan's Publications (10)