David R Hagen

David R Hagen, B.A., B.S.

(Ph.D. in progress)
  • Position:
    Graduate Student - Ph.D.

    Biological Engineering

    Massachusetts Institute of Technology (Cambridge, MA)

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  • Advisor:

    Bruce Tidor

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  • Degrees:
     
    Ph.D. (in progress), Biological Engineering, Massachusetts Institute of Technology (Cambridge, MA)
     
    B.S., Biochemistry, Case Western Reserve University (Cleveland, OH)
     
    B.A., Economics, Case Western Reserve University (Cleveland, OH)
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  • Past Advisors:
     
    Richard W Hanson (as Undergraduate Student)
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  • Research:
    I work on computational modeling to provide insight into improving experimental design.

    My research is focused on developing and applying computational tools for creating and using models of biomolecular systems. My overall goal is to complete the circuit of knowledge from system to topology to parameterization to prediction and design with tools that quantify and maximize our knowledge of biological systems. I am currently working on two experimental design algorithms that (1) select the best experiments for minimizing parameter uncertainty of a given model and (2) select the best experiments for eliminating competing topologies of a biological system.

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Life Sciences
Communities:

David Hagen's Genealogy

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David Hagen's Publications (1)



David Hagen's Posters and Presentations (1)

  • Optimal Experimental Design to Maximize Knowledge of Biological Systems (poster)

    David R Hagen, Joshua F Apgar, David K Witmer, and Bruce Tidor

    MIT-Merck, Computational & Systems Biology Symposium; 04/2010

One Figure

One Figure for David R Hagen

Much of the lab's system's biology tools are integrated into a Matlab toolbox called Kronecker Bio. This figure shows a highly nonlinear model successfully fit to some data. The parameters had been scrambled but could still be fit reliably and robustly.


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