Epernicus: Dyke P McEwen, Ph.D.

Dyke P McEwen, Ph.D.

Position:
Application Scientist

Biotechnology

Essen BioScience
Degrees:

Ph.D., Pharmacology, University of Michigan Medical School (Ann Arbor, MI)

B.A., Chemistry and Biology, Kalamazoo College (Kalamazoo, MI)
Past Advisors:

Jeffrey R Martens (as Post Doctoral Fellow)

John Caldwell (as Post Doctoral Fellow)

Lori L Isom (as Graduate Student - Ph.D.)
Research:
I study in vitro angiogenesis using a co-culture assay in conjunction with our IncuCyte instrument allowing for long-term, live cell imaging over the course of a 14 day angiogenesis assay.

Communities:

Dyke McEwen's Genealogy

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Dyke McEwen's Publications (19)

Single molecule imaging reveals differences in microtubule track selection between Kinesin motors.
Cai D, McEwen DP, Martens JR, Meyhofer E, Verhey KJ

PLoS biology. 2009 Oct;7(10):e1000216
The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin.
McEwen DP, Chen C, Meadows LS, Lopez-Santiago L, Isom LL

Neuroscience letters. 2009 Oct 25;462(3):272-5
Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.
Schumacher SM, McEwen DP, Zhang L, Arendt KL, Van Genderen KM, Martens JR

Circulation research. 2009 Jun 19;104(12):1390-8
Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome.
Layman WS, McEwen DP, Beyer LA, Lalani SR, Fernbach SD, Oh E, Swaroop A, Hegg CC, Raphael Y, Martens JR, Martin DM

Human molecular genetics. 2009 Jun 1;18(11):1909-23
Olfactory cilia: linking sensory cilia function and human disease.
Jenkins PM, McEwen DP, Martens JR

Chemical senses. 2009 Jun;34(5):451-64
Antifibrillatory agents and potassium channels in the atria: pore block versus channel trafficking.
McEwen DP, Martens JR

Molecular interventions. 2009 Apr;9(2):79-86
Caveolin regulates kv1.5 trafficking to cholesterol-rich membrane microdomains.
McEwen DP, Li Q, Jackson S, Jenkins PM, Martens JR

Molecular pharmacology. 2008 Mar;73(3):678-85
Olfactory cilia: our direct neuronal connection to the external world.
McEwen DP, Jenkins PM, Martens JR

Current topics in developmental biology. 2008;85:333-70
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.
Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL

Journal of molecular and cellular cardiology. 2007 Nov;43(5):636-47
Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons.
McEwen DP, Koenekoop RK, Khanna H, Jenkins PM, Lopez I, Swaroop A, Martens JR

Proceedings of the National Academy of Sciences of the United States of America. 2007 Oct 2;104(40):15917-22
Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes.
McEwen DP, Schumacher SM, Li Q, Benson MD, Iñiguez-Lluhí JA, Van Genderen KM, Martens JR

The Journal of biological chemistry. 2007 Oct 5;282(40):29612-20
Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.
Jenkins PM, Hurd TW, Zhang L, McEwen DP, Brown RL, Margolis B, Verhey KJ, Martens JR

Current biology : CB. 2006 Jun 20;16(12):1211-6
Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules.
McEwen DP, Isom LL

The Journal of biological chemistry. 2004 Dec 10;279(50):52744-52
A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction.
Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, Soltesz I, Benna P, Montalenti E, Isom LL, Goldin AL, Meisler MH

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Nov 3;24(44):10022-34
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.
Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Apr 21;24(16):4030-42
Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin.
McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL

The Journal of biological chemistry. 2004 Apr 16;279(16):16044-9
Fluorescence approaches to study G protein mechanisms.
McEwen DP, Gee KR, Kang HC, Neubig RR

Methods in enzymology. 2002;344:403-20
Contactin associates with Na+ channels and increases their functional expression.
Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Oct 1;21(19):7517-25
Fluorescent BODIPY-GTP analogs: real-time measurement of nucleotide binding to G proteins.
McEwen DP, Gee KR, Kang HC, Neubig RR

Analytical biochemistry. 2001 Apr 1;291(1):109-17

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Dyke P McEwen, Ph.D.

Application Scientist

I study in vitro angiogenesis using a co-culture assay in conjunction with our IncuCyte instrument allowing for long-term, live cell imaging over the course of a 14 day angiogenesis assay.

Dyke McEwen's Genealogy

Dyke McEwen's Publications (19)

Websites