Epernicus: DHIRENDRA K Simanshu, Ph.D.

DHIRENDRA K Simanshu, Ph.D.

Position:
Research Associate

Structural Biology

Memorial Sloan-Kettering Cancer Center (New York, NY)
Advisor:
Dinshaw J Patel
Degrees:

Ph.D., Biophysics and Structural Biology, Indian Institute of Science, Bangalore, India

M.Sc., Biotechnology, Jawaharlal Nehru University, New Delhi, India

B.Sc., Biotechnology, St. Columba's College, Vinoba Bhave University, Hazaribag, India
Past Advisors:

Murthy M. R. N (as Graduate Student - Ph.D.)
Research:

Communities:

DHIRENDRA Simanshu's Genealogy

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DHIRENDRA Simanshu's Publications (17)

Dicer recognizes the 5' end of RNA for efficient and accurate processing.
Park JE, Heo I, Tian Y, Simanshu DK, Chang H, Jee D, Patel DJ, Kim VN

Nature. 2011 Jul 14;475(7355):201-5
Conformational folding and stability of the HET-C2 glycolipid transfer protein fold: does a molten globule-like state regulate activity?
Kenoth R, Kamlekar RK, Simanshu DK, Gao Y, Malinina L, Prendergast FG, Molotkovsky JG, Patel DJ, Venyaminov SY, Brown RE

Biochemistry. 2011 Jun 14;50(23):5163-71
Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
Tian Y, Simanshu DK, Ascano M, Diaz-Avalos R, Park AY, Juranek SA, Rice WJ, Yin Q, Robinson CV, Tuschl T, Patel DJ

Nature structural & molecular biology. 2011 Jun;18(6):658-64
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo.
Rajakumara E, Law JA, Simanshu DK, Voigt P, Johnson LM, Reinberg D, Patel DJ, Jacobsen SE

Genes & development. 2011 Jan 15;25(2):137-52
Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.
Tian Y, Simanshu DK, Ma JB, Patel DJ

Proceedings of the National Academy of Sciences of the United States of America. 2011 Jan 18;108(3):903-10
Preliminary X-ray crystallographic analysis of 2-methylcitrate synthase from Salmonella typhimurium.
Chittori S, Simanshu DK, Savithri HS, Murthy MR

Acta crystallographica. Section F, Structural biology and crystallization communications. 2010 Apr 1;66(Pt 4):467-70
Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold.
Kenoth R, Simanshu DK, Kamlekar RK, Pike HM, Molotkovsky JG, Benson LM, Bergen HR, Prendergast FG, Malinina L, Venyaminov SY, Patel DJ, Brown RE

The Journal of biological chemistry. 2010 Apr 23;285(17):13066-78
Systematic study on crystal-contact engineering of diphthine synthase: influence of mutations at crystal-packing regions on X-ray diffraction quality.
Mizutani H, Saraboji K, Malathy Sony SM, Ponnuswamy MN, Kumarevel T, Krishna Swamy BS, Simanshu DK, Murthy MR, Kunishima N

Acta crystallographica. Section D, Biological crystallography. 2008 Oct;64(Pt 10):1020-33
Crystal structures of Salmonella typhimurium propionate kinase and its complex with Ap4A: evidence for a novel Ap4A synthetic activity.
Simanshu DK, Savithri HS, Murthy MR

Proteins. 2008 Mar;70(4):1379-88
Structure and function of enzymes involved in the anaerobic degradation of L-threonine to propionate.
Simanshu DK, Chittori S, Savithri HS, Murthy MR

Journal of biosciences. 2007 Sep;32(6):1195-206
Structure of the putative mutarotase YeaD from Salmonella typhimurium: structural comparison with galactose mutarotases.
Chittori S, Simanshu DK, Savithri HS, Murthy MR

Acta crystallographica. Section D, Biological crystallography. 2007 Feb;63(Pt 2):197-205
Crystal structures of Salmonella typhimurium biodegradative threonine deaminase and its complex with CMP provide structural insights into ligand-induced oligomerization and enzyme activation.
Simanshu DK, Savithri HS, Murthy MR

The Journal of biological chemistry. 2006 Dec 22;281(51):39630-41
Crystallization and preliminary X-ray crystallographic analysis of biodegradative threonine deaminase (TdcB) from Salmonella typhimurium.
Simanshu DK, Chittori S, Savithri HS, Murthy MR

Acta crystallographica. Section F, Structural biology and crystallization communications. 2006 Mar 1;62(Pt 3):275-8
Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.
Simanshu DK, Savithri HS, Murthy MR

Journal of molecular biology. 2005 Sep 30;352(4):876-92
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium.
Simanshu DK, Murthy MR

Acta crystallographica. Section F, Structural biology and crystallization communications. 2005 Jan 1;61(Pt 1):52-5
Crystal structure of Salmonella typhimurium 2-methylisocitrate lyase (PrpB) and its complex with pyruvate and Mg(2+).
Simanshu DK, Satheshkumar PS, Savithri HS, Murthy MR

Biochemical and biophysical research communications. 2003 Nov 7;311(1):193-201
Cloning, expression, purification and preliminary X-ray crystallographic studies of 2-methylisocitrate lyase from Salmonella typhimurium.
Simanshu DK, Satheshkumar PS, Parthasarathy S, Savithri HS, Murthy MR

Acta crystallographica. Section D, Biological crystallography. 2002 Dec;58(Pt 12):2159-61

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DHIRENDRA K Simanshu, Ph.D.

Research Associate

DHIRENDRA Simanshu's Genealogy

DHIRENDRA Simanshu's Publications (17)