Daniel F Gaddy, Ph.D.
- Positions:
Post Doctoral Fellow
Microbiology and Molecular Genetics
University of Pittsburgh School of Medicine (Pittsburgh, PA)
Editor, Science Writer, Technical Advisor
Fund Science
- Advisor:
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Degrees:
Ph.D., Microbiology & Immunology, Wake Forest University School of Medicine (Winston-Salem, NC)B.S., Microbiology, North Carolina State University (Raleigh, NC)
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Past Advisors:
Douglas S. Lyles (as Graduate Student - Ph.D.)
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Research:
Molecular biologist with a broad, multidisciplinary skillset, working in the area of Gene Therapy for autoimmune diseases.
I am currently a Postdoctoral Fellow in the laboratory of Dr. Paul Robbins at the University of Pittsburgh School of Medicine. My Postdoctoral work has focused on developing and testing AAV as a vector for gene therapy of type-1 and type-2 diabetes. I have successfully utilized AAV vectors expressing therapeutic genes, including the immunomodulatory molecule IL-4 and the beta cell growth factors GLP-1 and HGF, to induce beta cell proliferation and reverse diabetes in mouse models of type-1 and type-2 diabetes. In addition, I am now using AAV vectors and retrovirus vectors for gene therapy of premature aging.
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Honors:
2007-present Juvenile Diabetes Research Foundation Postdoctoral Fellowship
1998-present Golden Key National Honor Society
2007 Travel Award, 10th Annual Meeting of the American Society of Gene Therapy
2005 Travel Award, 24th Annual Meeting of the American Society for Virology
2003-2005 WFU Dept. of Microbiology and Immunology Ruth L. Kirschstein National Research Service Award
1998-1999 Gamma Sigma Delta Sophomore Scholarship
Daniel Gaddy's Genealogy
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Daniel Gaddy's Publications (10)
Daniel Gaddy's Posters and Presentations (8)
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DsAAV8-mediated expression of GLP-1 in pancreatic beta-cells prevents streptozotocin-induced diabetes. (presentation)
Michael J. Riedel, Daniel F Gaddy, Paul D. Robbins, Timothy J. Kieffer
Canadian Diabetes Association, Montreal, QC, Canada; 10/2008 -
DsAAV8-mediated expression of IL-4 and β cell growth factors modulates diabetes in NOD mice. (presentation)
Daniel F. Gaddy, Michael J. Riedel, Timothy J. Kieffer, Paul D. Robbins
11th Annual Meeting of the American Society of Gene Therapy, Boston, MA, USA; 06/2008 -
Comparison of rAAV serotypes for therapeutic gene transfer to islets for abrogation of autoimmunity in diabetes. (presentation)
Daniel F. Gaddy, Khaja K. Rehman, Suzanne Bertera, Nick Giannoukakis, and Paul D. Robbins
10th Annual Meeting of the American Society of Gene Therapy, Seattle, WA, USA; 06/2007 -
Oncolytic vesicular stomatitis virus induces apoptosis via signaling through PKR, Fas and Daxx. (poster)
Daniel F. Gaddy and Douglas S. Lyles
9th Annual Meeting of the American Society of Gene Therapy, Baltimore, MD, USA; 06/2006 -
Analysis of host gene products that contribute to the induction of apoptosis by vesicular stomatitis virus. (presentation)
Daniel F. Gaddy and Douglas S. Lyles
24th Annual Meeting of the American Society for Virology, State College, PA, USA; 07/2005 -
Analysis of host gene products that contribute to the induction of apoptosis by vesicular stomatitis virus. (presentation)
Daniel F. Gaddy and Douglas S. Lyles
23rd Annual Meeting of the American Society for Virology, Montreal, QC, Canada; 07/2004 -
Analysis of host gene products that contribute to the induction of apoptosis by vesicular stomatitis virus. (presentation)
Daniel F. Gaddy and Douglas S. Lyles
8th Southeastern Regional Virology Conference, Atlanta, GA, USA; 03/2004 -
Can phosphatase inhibitors be used to enhance apoptosis induced by chemotherapeutic agents? (poster)
Daniel F. Gaddy and Scott M. Laster
NCSU Undergraduate Research Symposium, Raleigh, NC, USA; 05/2000
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