Epernicus: Douglas A Rubinson, M.D., Ph.D.

Douglas A Rubinson, M.D., Ph.D.

Position:
Clinical Fellow

Medical Oncology

Dana-Farber Cancer Institute (Boston, MA)
Advisor:
Nabeel Bardeesy
Degrees:

M.D., Harvard Medical School (Boston, MA)

Ph.D., Biology, Massachusetts Institute of Technology (Cambridge, MA)

B.S., Molecular Biophsyics and Biochemistry, Yale University (New Haven, CT)

M.S., Molecular Biophyiscs and Biochemistry, Yale University (New Haven, CT)
Clinical Training:

Fellowship (in progress), Medical Oncology, Dana-Farber Cancer Institute

Residency, Internal Medicine, Brigham and Women's Hospital

Internship, Internal Medicine, Brigham and Women's Hospital
Past Advisors:

Frank B Gertler (as Graduate Student - Ph.D.)

Sandra L Wolin (as Undergraduate Student)
Research:
Honors:
2003 Ludwig Fellow in Cancer Research

1996-1998 Howard Hughes Undergraduate Research Fellow

Communities:

Douglas Rubinson's Genealogy

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Douglas Rubinson's Publications (11)

Filopodia are required for cortical neurite initiation.
Dent EW, Kwiatkowski AV, Mebane LM, Philippar U, Barzik M, Rubinson DA, Gupton S, Van Veen JE, Furman C, Zhang J, Alberts AS, Mori S, Gertler FB

Nature cell biology. 2007 Dec;9(12):1347-59
Ena/VASP is required for endothelial barrier function in vivo.
Furman C, Sieminski AL, Kwiatkowski AV, Rubinson DA, Vasile E, Bronson RT, Fässler R, Gertler FB

The Journal of cell biology. 2007 Nov 19;179(4):761-75
Ena/VASP Is Required for neuritogenesis in the developing cortex.
Kwiatkowski AV, Rubinson DA, Dent EW, Edward van Veen J, Leslie JD, Zhang J, Mebane LM, Philippar U, Pinheiro EM, Burds AA, Bronson RT, Mori S, Fässler R, Gertler FB

Neuron. 2007 Nov 8;56(3):441-55
Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes.
Dillon CP, Sandy P, Nencioni A, Kissler S, Rubinson DA, Van Parijs L

Annual review of physiology. 2005;67:147-73
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.
Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB

Developmental cell. 2004 Oct;7(4):571-83
A La protein requirement for efficient pre-tRNA folding.
Chakshusmathi G, Kim SD, Rubinson DA, Wolin SL

The EMBO journal. 2003 Dec 15;22(24):6562-72
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference.
Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, Gertler FB, Scott ML, Van Parijs L

Nature genetics. 2003 Mar;33(3):401-6
ARF mutation accelerates pituitary tumor development in Rb+/- mice.
Tsai KY, MacPherson D, Rubinson DA, Nikitin AY, Bronson R, Mercer KL, Crowley D, Jacks T

Proceedings of the National Academy of Sciences of the United States of America. 2002 Dec 24;99(26):16865-70
Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration.
Loureiro JJ, Rubinson DA, Bear JE, Baltus GA, Kwiatkowski AV, Gertler FB

Molecular biology of the cell. 2002 Jul;13(7):2533-46
ARF is not required for apoptosis in Rb mutant mouse embryos.
Tsai KY, MacPherson D, Rubinson DA, Crowley D, Jacks T

Current biology : CB. 2002 Jan 22;12(2):159-63
U snRNP assembly in yeast involves the La protein.
Xue D, Rubinson DA, Pannone BK, Yoo CJ, Wolin SL

The EMBO journal. 2000 Apr 3;19(7):1650-60

Douglas Rubinson's Posters and Presentations (2)

The Ena/VASP triple-knockout uncovers functions in mouse development (presentation)
Douglas A Rubinson

The 18th Cell Biology Symposium, Nagoya Japan; 11/2004
Implications of RNAi in therapeutic target identification and drug discovery (presentation)
Douglas A Rubinson

IBC Model Organisms in Drug Discovery; 08/2003

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Douglas A Rubinson, M.D., Ph.D.

Clinical Fellow

Douglas Rubinson's Genealogy

Douglas Rubinson's Publications (11)

Douglas Rubinson's Posters and Presentations (2)