Carlo Zambonelli

Carlo Zambonelli, Ph.D.

  • Position:
    Research Scientist

    Protein Biochemistry

    Cambridge, MA

    Novartis Vaccines and Diagnostics (Basel, Switzerland)

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  • Advisors:

    Mara Prentiss, Nancy Kleckner

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  • Degrees:
     
    Ph.D., Biochemistry, University of Milan (Milan, Italy)
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  • Past Advisors:
     
    Mary F Roberts (as Post Doctoral Fellow)
     
    Andrea Mozzarelli (as Graduate Student - Masters)
     
    Gian Luigi Rossi (as Graduate Student - Masters)
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  • Research:
    1) Characterization of mechanical properties of HEAT domain proteins; 2) Formation of RecA filament during the mechanical unzipping of dsDNA to ssDNA.

    HEAT Repeat Domains as Protein Springs. Many molecules can act as springs with the function of detecting mechanical stress exerted by the expansion/contraction of their substrates. We are characterizing PIKKs as possible molecular springs: the structural unit is the HEAT domain, two short, interacting, antiparallel helices organized in flexible higher order gyres composed of 40-60 domains. We are exploring both single molecule and ensemble methods for measuring force extension curves related to elastic properties of individual proteins.

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  • Other Experience:

    1993-1995 Staff Scientist - Ematology and Transfusion lab

Life Sciences
Communities:

Carlo Zambonelli's Genealogy

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Carlo Zambonelli's Publications (11)



One Figure

One Figure for Carlo Zambonelli

Computational model of Streptomyces chromofuscus PLD


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