Epernicus: Christian Ungermann, Ph.D.

Christian Ungermann, Ph.D.

Position:
Full Professor

Biology

University of Osnabrueck (Osnabruck, Germany)
Degrees:

Ph.D., Biochemistry, Ludwig Maximilian University of Munich (Munich, Germany)

M.Sc., Biochemistry and Biophysics, Oregon State University (Corvallis, OR)
Past Advisors:
Research:
Regulation of membrane dynamics at endosomes and vacuoles in Eukaryots

Eukaryotic cells contain an extensive endomembrane system. Transport of proteins and lipids within this system occurs on vesicles, which pinch off from one membrane and fuse with the next. To maintain identity of each organelle, fission and fusion need to be balanced.

Within our group, we are interested in intracellular membrane dynamics and focus on the yeast endocytic pathway, in particular on the vacuole (the lysosome-equivalent of yeast). The main focus is the fusion machinery, which is conserved among eukaryots, and includes tethers, Rabs and SNAREs. In this context, we have developed a strong interest in postranslational modifications like protein palmitoylation and phosphorylation.

Communities:

Christian Ungermann's Genealogy

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Christian Ungermann's Publications (45)

Depalmitoylation of ykt6 prevents its entry into the multivesicular body pathway.
Meiringer CT, Auffarth K, Hou H, Ungermann C

Traffic (Copenhagen, Denmark). 2008 Sep;9(9):1510-21
UVRAG reveals its second nature.
Peplowska K, Cabrera M, Ungermann C

Nature cell biology. 2008 Jul;10(7):759-61
Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.
Pylypenko O, Schönichen A, Ludwig D, Ungermann C, Goody RS, Rak A, Geyer M

Journal of molecular biology. 2008 Apr 11;377(5):1334-45
The vacuolar V1/V0-ATPase is involved in the release of the HOPS subunit Vps41 from vacuoles, vacuole fragmentation and fusion.
Takeda K, Cabrera M, Rohde J, Bausch D, Jensen ON, Ungermann C

FEBS letters. 2008 Apr 30;582(10):1558-63
Yeast vacuole fusion: a model system for eukaryotic endomembrane dynamics.
Ostrowicz CW, Meiringer CT, Ungermann C

Autophagy. 2008 Jan 1;4(1):5-19
Rab cascades and tethering factors in the endomembrane system.
Markgraf DF, Peplowska K, Ungermann C

FEBS letters. 2007 May 22;581(11):2125-30
The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.
Peplowska K, Markgraf DF, Ostrowicz CW, Bange G, Ungermann C

Developmental cell. 2007 May;12(5):739-50
The role of transmembrane domains in membrane fusion.
Langosch D, Hofmann M, Ungermann C

Cellular and molecular life sciences : CMLS. 2007 Apr;64(7-8):850-64
Self-interaction of a SNARE transmembrane domain promotes the hemifusion-to-fusion transition.
Hofmann MW, Peplowska K, Rohde J, Poschner BC, Ungermann C, Langosch D

Journal of molecular biology. 2006 Dec 15;364(5):1048-60
Probing protein palmitoylation at the yeast vacuole.
Meiringer CT, Ungermann C

Methods (San Diego, Calif.). 2006 Oct;40(2):171-6
Palmitoylation determines the function of Vac8 at the yeast vacuole.
Subramanian K, Dietrich LE, Hou H, LaGrassa TJ, Meiringer CT, Ungermann C

Journal of cell science. 2006 Jun 15;119(Pt 12):2477-85
Role of the Vam3p transmembrane segment in homodimerization and SNARE complex formation.
Roy R, Peplowska K, Rohde J, Ungermann C, Langosch D

Biochemistry. 2006 Jun 20;45(24):7654-60
The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8.
Hou H, Subramanian K, LaGrassa TJ, Markgraf D, Dietrich LE, Urban J, Decker N, Ungermann C

Proceedings of the National Academy of Sciences of the United States of America. 2005 Nov 29;102(48):17366-71
Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing.
Ungermann C, Langosch D

Journal of cell science. 2005 Sep 1;118(Pt 17):3819-28
ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles.
Dietrich LE, LaGrassa TJ, Rohde J, Cristodero M, Meiringer CT, Ungermann C

The Journal of biological chemistry. 2005 Apr 15;280(15):15348-55
The SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion.
Dietrich LE, Peplowska K, LaGrassa TJ, Hou H, Rohde J, Ungermann C

EMBO reports. 2005 Mar;6(3):245-50
Expanding dynamin: from fission to fusion.
Peplowska K, Ungermann C

Nature cell biology. 2005 Feb;7(2):103-4
The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex.
LaGrassa TJ, Ungermann C

The Journal of cell biology. 2005 Jan 31;168(3):401-14
Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators.
Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D'Esposito M, Galli T, Filippini F

Trends in biochemical sciences. 2004 Dec;29(12):682-8
On the mechanism of protein palmitoylation.
Dietrich LE, Ungermann C

EMBO reports. 2004 Nov;5(11):1053-7
Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.
Faergeman NJ, Feddersen S, Christiansen JK, Larsen MK, Schneiter R, Ungermann C, Mutenda K, Roepstorff P, Knudsen J

The Biochemical journal. 2004 Jun 15;380(Pt 3):907-18
The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion.
Dietrich LE, Gurezka R, Veit M, Ungermann C

The EMBO journal. 2004 Jan 14;23(1):45-53
Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins.
Dietrich LE, Boeddinghaus C, LaGrassa TJ, Ungermann C

Biochimica et biophysica acta. 2003 Aug 18;1641(2-3):111-9
Biochemical characterization of the vacuolar palmitoyl acyltransferase.
Veit M, Dietrich LE, Ungermann C

FEBS letters. 2003 Apr 10;540(1-3):101-5
The transmembrane domain of Vam3 affects the composition of cis- and trans-SNARE complexes to promote homotypic vacuole fusion.
Rohde J, Dietrich L, Langosch D, Ungermann C

The Journal of biological chemistry. 2003 Jan 17;278(3):1656-62

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Ungermann lab

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