Charles T Drinnan, Ph.D.
- Position:
Graduate Student - Ph.D.
Biomedical Engineering
University of Texas at Austin (Austin, TX)
- Advisor:
-
Degrees:
Ph.D., Biomedical Engineering, University of Texas at Austin (Austin, TX)M.S., Biomedical Engineering, University of Texas at Austin (Austin, TX)B.S., Biomedical Engineering, Tulane University (New Orleans, LA)
-
Past Advisors:
J-K Francis Suh (as Undergraduate Student)
-
Research:
Development of a combinational paracrine factor delivery and PEGylated fibrin gel to direct mesenchymal stem cell (MSC) differentiation towards a vascular line
The objective of the project is to develop a combinational paracrine factor delivery and PEGylated fibrin gel to direct mesenchymal stem cell (MSC) differentiation towards a vascular line. We have previously demonstrated that MSCs will form de novo endothelial tubes when embedded within PEGylated fibrin gels. Further, markers for smooth muscle cells (SMC) were upregulated. Thus, we could form a fully functioning vascular network containing both endothelial and pericyte cells from the same progenitor population. To promote SMC differentiation, multiple growth factors can be loaded into the PEGylated fibrin gel through 3 mechanisms: 1) covalent conjugation leading to a zero-order release, 2) admixing of the paracrine factor leading to a diffusion controlled release, and 3) physical association of the paracrine factor with the matrix leading to degradation-controlled release. Multiple release profiles allow for precise temporal presentation of paracrine factors to promote MSC proliferation and differentiation.
-
Other Experience:
2003-2004 Waterborne, Inc.
Charles Drinnan's Genealogy
The Adobe Flash Player plugin (version 8) is required to view the genealogy tree.
Download the plugin here.
Already a member?
Sign in to view Charles's full profile.