Epernicus: Chozha Vendan Rathinam, Ph.D.

Chozha Vendan Rathinam, Ph.D.

Position:
Assistant Professor

Genetics and Development

Columbia University Medical Center (New York, NY)
Degrees:

Ph.D., Immunology, Hannover Medical School (Hannover, Germany)
Past Advisors:

Dr.Richard Flavell (as Post Doctoral Fellow)

Dr. Christoph Klein (as Graduate Student - Ph.D.)
Research:
Decoding the genetic and molecular bases of stem cell self-renewal through ubiquitylation

The overall goal of my research team is to delineate the molecular and biochemical bases of self-renewal of stem cells. In particular, we aim to understand how post-translational modifications of proteins regulate the “stemness” of stem cells.
The major lines of our current investigation include:
1. Decode the genetic basis of self-renewal of Hematopoietic Stem Cells:
2. Decipher aberrant molecular events that give rise to Leukemic Stem Cells:
3. Unravel the molecular identities of Mesenchymal Stem Cells:
Other Experience:
2010-2011 Head, Laboratory of Stem cell Biology, NIH center for Excellence in Stem Cell Biology

Communities:

Chozha Vendan Rathinam's Genealogy

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Chozha Vendan Rathinam's Publications (22)

Transgenic expression of human signal regulatory protein alpha in Rag2-/-{gamma}c-/- mice improves engraftment of human hematopoietic cells in humanized mice.
Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA

Proceedings of the National Academy of Sciences of the United States of America. 2011 Aug 9;108(32):13218-23
Efficient differentiation and function of human macrophages in humanized CSF-1 mice.
Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA

Blood. 2011 Jul 25
Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.
Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA

The Journal of experimental medicine. 2011 May 9;208(5):1027-40
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.
Rathinam C, Matesic LE, Flavell RA

Nature immunology. 2011 May;12(5):399-407
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA

Proceedings of the National Academy of Sciences of the United States of America. 2011 Feb 8;108(6):2378-83
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
Rathinam C, Thien CB, Flavell RA, Langdon WY

Cancer cell. 2010 Oct 19;18(4):341-52
c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.
Rathinam C, Flavell RA

Proceedings of the National Academy of Sciences of the United States of America. 2010 May 4;107(18):8316-21
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance.
Kriegel MA, Rathinam C, Flavell RA

Proceedings of the National Academy of Sciences of the United States of America. 2009 Sep 29;106(39):16770-5
Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P

Cell host & microbe. 2009 Jul 23;6(1):5-9
MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.
Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, Kotlyarov A, Klein C, Gaestel M

The EMBO journal. 2009 May 20;28(10):1392-406
The hematopoiesis paradigm: clarity or ambiguity?
Rathinam C, Flavell RA

Blood. 2008 Nov 1;112(9):3534-5
Transcription factor Gfi1 restricts B cell-mediated autoimmunity.
Rathinam C, Lassmann H, Mengel M, Klein C

Journal of immunology (Baltimore, Md. : 1950). 2008 Nov 1;181(9):6222-9
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
Rathinam C, Thien CB, Langdon WY, Gu H, Flavell RA

Genes & development. 2008 Apr 15;22(8):992-7
Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin.
Templin C, Kotlarz D, Rathinam C, Rudolph C, Schätzlein S, Ramireddy K, Rudolph KL, Schlegelberger B, Klein C, Drexler H

Experimental hematology. 2008 Feb;36(2):204-15
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.
Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A, Rudolph KL

Nature medicine. 2007 Jun;13(6):742-7
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
Bohn G, Allroth A, Brandes G, Thiel J, Glocker E, Schäffer AA, Rathinam C, Taub N, Teis D, Zeidler C, Dewey RA, Geffers R, Buer J, Huber LA, Welte K, Grimbacher B, Klein C

Nature medicine. 2007 Jan;13(1):38-45
HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease).
Klein C, Grudzien M, Appaswamy G, Germeshausen M, Sandrock I, Schäffer AA, Rathinam C, Boztug K, Schwinzer B, Rezaei N, Bohn G, Melin M, Carlsson G, Fadeel B, Dahl N, Palmblad J, Henter JI, Zeidler C, Grimbacher B, Welte K

Nature genetics. 2007 Jan;39(1):86-92
Transcriptional repressor Gfi1 integrates cytokine-receptor signals controlling B-cell differentiation.
Rathinam C, Klein C

PloS one. 2007;2(3):e306
Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2.
Jung J, Bohn G, Allroth A, Boztug K, Brandes G, Sandrock I, Schäffer AA, Rathinam C, Köllner I, Beger C, Schilke R, Welte K, Grimbacher B, Klein C

Blood. 2006 Jul 1;108(1):362-9
Generation and characterization of a novel hematopoietic progenitor cell line with DC differentiation potential.
Rathinam C, Sauer M, Ghosh A, Rudolph C, Hegazy A, Schlegelberger B, Welte K, Klein C

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2006 May;20(5):870-6
The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function.
Rathinam C, Geffers R, Yücel R, Buer J, Welte K, Möröy T, Klein C

Immunity. 2005 Jun;22(6):717-28
Evidence for polyadenylated mRNA in Pseudomonas aeruginosa.
Saravanamuthu SS, von Götz F, Salunkhe P, Chozhavendan R, Geffers R, Buer J, Tümmler B, Steinmetz I

Journal of bacteriology. 2004 Oct;186(20):7015-8

Websites

Rathinam Lab

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