Charles Liu

Charles Liu

(A.B. in progress)
  • Position:
    Undergraduate

    Harvard University (Cambridge, MA)

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  • Advisor:

    Daniel E. Kahne

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  • Degrees:
     
    A.B. (in progress), Molecular and Cellular Biology, Harvard University (Cambridge, MA)
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  • Past Advisors:
     
    Dean W. Felsher (as Visiting Student)
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  • Research:
    Periplasmic transit of lipopolysaccharide (LPS) during bacterial outer membrane biogenesis

    The cell envelope of gram-negative bacteria consists of an inner (IM) and an outer membrane (OM) separated by an aqueous space, the periplasm, containing the peptidoglycan cell wall. The OM is asymmetric, with phospholipids in its inner leaflet and lipopolysaccharide (LPS) in its outer leaflet. LPS plays a crucial role in the OM’s barrier function and is essential for survival in most gram-negative bacteria, but until recently little was known about its transport to the OM. Our lab studies the LPS transport pathway, providing insight into the unique process of OM biogenesis and uncovering potential targets for novel antibiotics, which are urgently needed to address the burgeoning global health threat posed by antibiotic-resistant bacterial infections.

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  • Other Experience:

    2008 Fellow, Harvard College Program for Research in Science and Engineering

    2008 Herschel Smith Summer Undergraduate Research Fellow

    2006 Summer Intern, Center for Clinical Immunology at Stanford

Life Sciences
Communities:

Charles Liu's Genealogy

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Charles Liu's Posters and Presentations (2)

  • Investigating periplasmic transit of lipopolysaccharide during bacterial outer membrane biogenesis (poster)

    Charles Liu, Daniel E. Kahne

    Harvard Undergraduate Research Symposium; 11/2008
  • p53 mutations alone are unlikely to be responsible for the escape from MYC dependence of MYC-induced lymphomas (poster)

    Charles Liu, Dean W. Felsher

    Harvard Undergraduate Research Symposium; 11/2007

One Figure

One Figure for Charles Liu

A model of LPS transport to the outer membrane, from Sperandeo, et al. (2008) Journal of Bacteriology, 190(13):4460-9.


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