Epernicus: Calvin K Yip, Ph.D.

Calvin K Yip, Ph.D.

Position:
Assistant Professor

Biochemistry & Molecular Biology

The University of British Columbia
Degrees:

Ph.D., Biochemistry, University of British Columbia (Vancouver, Canada)

B.Sc., Biochemistry, University of British Columbia (Vancouver, Canada)
Past Advisors:

Thomas Walz (as Post Doctoral Fellow)

Natalie Strynadka (as Graduate Student - Ph.D.)

B. Brett Finlay (as Undergraduate Student)

Connie Eaves (as Undergraduate Student)

Aly Karsan (as Undergraduate Student)

Michael Murphy (as Undergraduate Student)
Research:
Honors:
2009-2010 CIHR Jean-Francois St-Denis Fellowship in Cancer Research

2006-2009 Jane Coffin Childs Memorial Fund Fellowship

Communities:

Calvin Yip's Genealogy

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Calvin Yip's Publications (18)

Molecular architecture of the TRAPPII complex and implications for vesicle tethering.
Yip CK, Berscheminski J, Walz T

Nature structural & molecular biology. 2010 Nov;17(11):1298-304
Molecular organization of the COG vesicle tethering complex.
Lees JA, Yip CK, Walz T, Hughson FM

Nature structural & molecular biology. 2010 Nov;17(11):1292-7
The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.
Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC

Cell. 2010 Aug 20;142(4):556-67
Structure of the human mTOR complex I and its implications for rapamycin inhibition.
Yip CK, Murata K, Walz T, Sabatini DM, Kang SA

Molecular cell. 2010 Jun 11;38(5):768-74
A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.
Ren Y, Yip CK, Tripathi A, Huie D, Jeffrey PD, Walz T, Hughson FM

Cell. 2009 Dec 11;139(6):1119-29
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Spreter T, Yip CK, Sanowar S, André I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC

Nature structural & molecular biology. 2009 May;16(5):468-76
An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing.
Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, Moazed D

Molecular cell. 2009 Apr 24;34(2):155-67
Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa.
Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN

The Journal of biological chemistry. 2008 Jul 4;283(27):18655-64
Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.
Ohi MD, Feoktistova A, Ren L, Yip C, Cheng Y, Chen JS, Yoon HJ, Wall JS, Huang Z, Penczek PA, Gould KL, Walz T

Molecular cell. 2007 Dec 14;28(5):871-85
Structure-based mutagenesis of SigE verifies the importance of hydrophobic and electrostatic residues in type III chaperone function.
Knodler LA, Bertero M, Yip C, Strynadka NC, Steele-Mortimer O

Molecular microbiology. 2006 Nov;62(4):928-40
Structural polymorphism in bacterial EspA filaments revealed by cryo-EM and an improved approach to helical reconstruction.
Wang YA, Yu X, Yip C, Strynadka NC, Egelman EH

Structure (London, England : 1993). 2006 Jul;14(7):1189-96
New structural insights into the bacterial type III secretion system.
Yip CK, Strynadka NC

Trends in biochemical sciences. 2006 Apr;31(4):223-30
CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli.
Thomas NA, Deng W, Puente JL, Frey EA, Yip CK, Strynadka NC, Finlay BB

Molecular microbiology. 2005 Sep;57(6):1762-79
Structural characterization of the molecular platform for type III secretion system assembly.
Yip CK, Kimbrough TG, Felise HB, Vuckovic M, Thomas NA, Pfuetzner RA, Frey EA, Finlay BB, Miller SI, Strynadka NC

Nature. 2005 Jun 2;435(7042):702-7
Structural characterization of a type III secretion system filament protein in complex with its chaperone.
Yip CK, Finlay BB, Strynadka NC

Nature structural & molecular biology. 2005 Jan;12(1):75-81
Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa.
MacKenzie F, Duriez P, Larrivée B, Chang L, Pollet I, Wong F, Yip C, Karsan A

Blood. 2004 Sep 15;104(6):1760-8
Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo.
Jiang X, Ng E, Yip C, Eisterer W, Chalandon Y, Stuible M, Eaves A, Eaves CJ

Blood. 2002 Nov 15;100(10):3731-40
Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems.
Knodler LA, Celli J, Hardt WD, Vallance BA, Yip C, Finlay BB

Molecular microbiology. 2002 Mar;43(5):1089-103

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Calvin K Yip, Ph.D.

Assistant Professor

Calvin Yip's Genealogy

Calvin Yip's Publications (18)