Charles H Vannoy, Ph.D.
- Position:
Post Doctoral Fellow
Chemical and Physical Sciences
University of Toronto (Toronto, Canada)
- Advisors:
-
Degrees:
Ph.D., Chemistry, University of Miami (Coral Gables, FL)B.A., Chemistry, Southern Methodist University (Dallas, TX)B.S., Mathematics, Southern Methodist University (Dallas, TX)
- Past Advisors:
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Research:
Bioimaging of CdSe/ZnS quantum dots bioconjugated to amyloid proteins
Advances in recent nanoscience technology have generated a new compilation of fluorescent biolabels derived from semiconductor quantum dots. Due to their properties of being water-soluble and biocompatible, these nanometer-sized probes prove to be a beneficial tool for bioimaging.
Amyloid fibrils are self-associating filamentous structures that tend to aggregate in well-ordered intramolecular multiple β-sheet structures. The assembly of these amyloid fibrils is an important biological topic of study due to the fact that some amyloid fibrils are linked to the pathogenesis of multiple diseases.
In combining both of these systems by bioconjugation of the QDs to amyloid fibrils, we have created a specific fluorescent labeling system for potential application in nanobiotechnology.
Charles Vannoy's Genealogy
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One Figure
Schematic representation of the HEWL-QDs bioconjugate system. (1) Synthesis of DHLA-QDs (2) HEWL is bioconjugated to the DHLA-QDs. (3) The bioconjugated HEWL-QDs are incubated at 57°C for ~14 days to form the final product, HEWL fibrils with QDs embedded.
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