Epernicus: Christopher G Wilson, Ph.D.

Christopher G Wilson, Ph.D.

Position:
Post Doctoral Fellow

Center for Craniofacial Regeneration

Periodontics & Oral Medicine

University of Michigan (Ann Arbor, MI)
Advisor:
Renny T. Franceschi
Degrees:

Ph.D., Bioengineering, Georgia Institute of Technology (Atlanta, GA)

M.S., Biomedical Engineering, Worcester Polytechnic Institute (Worcester, MA)

B.S., Biomedical Engineering, Worcester Polytechnic Institute (Worcester, MA)
Past Advisors:

Edie C. Goldsmith (as Post Doctoral Fellow)

Marc E. Levenston (as Graduate Student - Ph.D.)

Lawrence J. Bonassar (as Graduate Student - Masters)
Research:
My primary research objective is to develop methods of promoting the ex vivo formation and in vivo regeneration of musculoskeletal tissues including cartilage, fibrocartilage, and bone. I am specifically interested in the dynamic regulatory relationships between extracellular matrix biochemistry, tissue mechanics, and population-level cell behavior during morphogenesis. Currently, I am using inducible gene expression circuits to drive the recruitment and subsequent differentiation of progenitor populations for the regeneration of bone. I am also interested in the use of surface-modified nanoparticles for regulating cell-mediated remodeling and the mechanical properties of the extracellular matrix.

Communities:

Christopher Wilson's Genealogy

The Adobe Flash Player plugin (version 8) is required to view the genealogy tree.
Download the plugin here.

Christopher Wilson's Publications (15)

Tensile loading modulates bone marrow stromal cell differentiation and the development of engineered fibrocartilage constructs.
Connelly JT, Vanderploeg EJ, Mouw JK, Wilson CG, Levenston ME

Tissue engineering. Part A. 2010 Jun;16(6):1913-23
Polyelectrolyte-coated gold nanorods and their interactions with type I collagen.
Wilson CG, Sisco PN, Gadala-Maria FA, Murphy CJ, Goldsmith EC

Biomaterials. 2009 Oct;30(29):5639-48
Composition-function relationships during IL-1-induced cartilage degradation and recovery.
Palmer AW, Wilson CG, Baum EJ, Levenston ME

Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2009 Aug;17(8):1029-39
Chondrocytes and meniscal fibrochondrocytes differentially process aggrecan during de novo extracellular matrix assembly.
Wilson CG, Nishimuta JF, Levenston ME

Tissue engineering. Part A. 2009 Jul;15(7):1513-22
Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications.
Wilson CG, Vanderploeg EJ, Zuo F, Sandy JD, Levenston ME

Arthritis research & therapy. 2009;11(6):R173
Glycosaminoglycan- Functionalized Gold Nanorods: Interactions With Cardiac Cells And Type I Collagen
Christopher G Wilson, Patrick N Sisco, Edie C Goldsmith, Catherine J Murphy

J Mat Chem. 2009;19:6332-40
Articular chondrocytes derived from distinct tissue zones differentially respond to in vitro oscillatory tensile loading.
Vanderploeg EJ, Wilson CG, Levenston ME

Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2008 Oct;16(10):1228-36
The effect of gold nanorods on cell-mediated collagen remodeling.
Sisco PN, Wilson CG, Mironova E, Baxter SC, Murphy CJ, Goldsmith EC

Nano letters. 2008 Oct;8(10):3409-12
Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs.
Connelly JT, Wilson CG, Levenston ME

Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2008 Sep;16(9):1092-100
A mechanical composite spheres analysis of engineered cartilage dynamics.
Kohles SS, Wilson CG, Bonassar LJ

Journal of biomechanical engineering. 2007 Aug;129(4):473-80
Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.
Wilson CG, Palmer AW, Zuo F, Eugui E, Wilson S, Mackenzie R, Sandy JD, Levenston ME

Matrix biology : journal of the International Society for Matrix Biology. 2007 May;26(4):259-68
Dynamic compression regulates the expression and synthesis of chondrocyte-specific matrix molecules in bone marrow stromal cells.
Mouw JK, Connelly JT, Wilson CG, Michael KE, Levenston ME

Stem cells (Dayton, Ohio). 2007 Mar;25(3):655-63
Modeling the dynamic composition of engineered cartilage.
Wilson CG, Bonassar LJ, Kohles SS

Archives of biochemistry and biophysics. 2002 Dec 15;408(2):246-54
Direct perfusion measurements of cancellous bone anisotropic permeability.
Kohles SS, Roberts JB, Upton ML, Wilson CG, Bonassar LJ, Schlichting AL

Journal of biomechanics. 2001 Sep;34(9):1197-202
The effect of ablation sequence and duration on lesion shape using rapidly pulsed radiofrequency energy through multiple electrodes.
McRury ID, Diamond S, Falwell G, Schlichting A, Wilson C

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2000 Apr;4(1):307-20

One Figure

Sagittal Suture of Mouse (postnatal day ~4). Bone is labeled with calcein (green) and alizarin red (red). Nuclei are labeled blue with Hoechst 33342. Captured with a Leica Multiphoton.

Websites

TEAM Training Grant Homepage

Join Epernicus (membership is free)

Epernicus is open to current and former research scientists.