Epernicus: Christian E Rocheleau, Ph.D.

Christian E Rocheleau, Ph.D.

Positions:
Associate Professor

Medicine

Anatomy and Cell Biology

McGill University (Montreal, Canada)

Medical Scientist

Research Institute of the McGill University Health Centre (Montreal, Canada)
Degrees:

Ph.D., Cell Biology, University of Massachusetts Medical School (Worcester, MA)

B.A., Biology, Assumption College (Worcester, MA)
Past Advisors:

Meera V. Sundaram (as Post Doctoral Fellow)

Craig C Mello (as Graduate Student - Ph.D.)
Research:
Cell signaling and endocytosis in C. elegans

Research in my laboratory uses C. elegans genetics and mammalian cell culture to study mechanisms regulating cell signaling, endocytosis and interactions between these cellular processes.
Honors:
2010-2013 Chercheur-boursier (Junior 2) Fonds de la recherche en santé du Québec

2005-2010 Canadian Research Chair in Signaling and Development

2000-2003 Jane Coffin Childs Memorial Fund for Cancer Research Fellowship

Communities:

Christian Rocheleau's Genealogy

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Christian Rocheleau's Publications (10)

TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans.
Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG, Rocheleau CE

Molecular biology of the cell. 2010 Jul 1;21(13):2285-96
TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans.
Chotard L, Skorobogata O, Sylvain MA, Shrivastava S, Rocheleau CE

PloS one. 2010;5(12):e15662
The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway.
Rocheleau CE, Cullison K, Huang K, Bernstein Y, Spilker AC, Sundaram MV

Genetics. 2008 Mar;178(3):1431-43
Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.
Rocheleau CE, Rönnlund A, Tuck S, Sundaram MV

Proceedings of the National Academy of Sciences of the United States of America. 2005 Aug 16;102(33):11757-62
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.
Bei Y, Hogan J, Berkowitz LA, Soto M, Rocheleau CE, Pang KM, Collins J, Mello CC

Developmental cell. 2002 Jul;3(1):113-25
A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.
Rocheleau CE, Howard RM, Goldman AP, Volk ML, Girard LJ, Sundaram MV

Genetics. 2002 May;161(1):121-31
C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.
Ohmachi M, Rocheleau CE, Church D, Lambie E, Schedl T, Sundaram MV

Current biology : CB. 2002 Mar 5;12(5):427-33
MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Shin TH, Yasuda J, Rocheleau CE, Lin R, Soto M, Bei Y, Davis RJ, Mello CC

Molecular cell. 1999 Aug;4(2):275-80
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans.
Rocheleau CE, Yasuda J, Shin TH, Lin R, Sawa H, Okano H, Priess JR, Davis RJ, Mello CC

Cell. 1999 Jun 11;97(6):717-26
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
Rocheleau CE, Downs WD, Lin R, Wittmann C, Bei Y, Cha YH, Ali M, Priess JR, Mello CC

Cell. 1997 Aug 22;90(4):707-16

One Figure

Enlarged LMP-1::GFP positive late endosomes in the intestinal cells of tbc-2 mutant C. elegans worms

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