Epernicus: Christopher D Snow, Ph.D.

Christopher D Snow, Ph.D.

Position:
Post Doctoral Fellow

Chemistry and Chemical Engineering

California Institute of Technology (Pasadena, CA)
Advisor:
Frances H. Arnold
Degrees:

Ph.D., Biophysics, Stanford University (Stanford, CA)

B.Sc., Chemistry, Massachusetts Institute of Technology (Cambridge, MA)
Past Advisors:

Vijay S. Pande (as Graduate Student - Ph.D.)

Bruce Tidor (as Undergraduate Student)
Research:
High resolution protein structure prediction and computational library design

I'm currently working with several teams of students, to (1) develop a new software platform (SHARPEN) for protein structure refinement, as well as protein design applications and (2) start running these calculations on the Folding@Home distributed computing network. I've been doing a bit of crystallography this last year, crystallizing the heme domain of P450 variants. Also, I've been working on P450 library design for various directed evolution efforts in the group.
Honors:
2008-present KAUST Postdoctoral Fellowship

2006-2008 Jane Coffin Childs Postdoctoral Fellowship

2006 NSF Bioinformatics Postdoctoral Fellowship (declined)

2004-2005 Protein Society Best Poster Awards

2001 Hypercube Computational Chemistry Award

2001 Phi Beta Kappa

2001 NSF Predoctoral Fellowship (declined)

2001-2006 HHMI Predoctoral Fellowship

2001 Outstanding Chemistry Research Achievement by an MIT Undergraduate

2000 Pfizer Summer Undergraduate Research Fellow

2000 MIT Nominee for Goldwater Scholarship

1997 National Merit Scholar

Communities:

Christopher Snow's Genealogy

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Christopher Snow's Publications (20)

SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability.
Heinzelman P, Snow CD, Smith MA, Yu X, Kannan A, Boulware K, Villalobos A, Govindarajan S, Minshull J, Arnold FH

The Journal of biological chemistry. 2009 Sep 25;284(39):26229-33
A family of thermostable fungal cellulases created by structure-guided recombination.
Heinzelman P, Snow CD, Wu I, Nguyen C, Villalobos A, Govindarajan S, Minshull J, Arnold FH

Proceedings of the National Academy of Sciences of the United States of America. 2009 Apr 7;106(14):5610-5
SHARPEN-systematic hierarchical algorithms for rotamers and proteins on an extended network.
Loksha IV, Maiolo JR, Hong CW, Ng A, Snow CD

Journal of computational chemistry. 2009 Apr 30;30(6):999-1005
Evolutionary history of a specialized p450 propane monooxygenase.
Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH

Journal of molecular biology. 2008 Nov 28;383(5):1069-80
Side-chain recognition and gating in the ribosome exit tunnel.
Petrone PM, Snow CD, Lucent D, Pande VS

Proceedings of the National Academy of Sciences of the United States of America. 2008 Oct 28;105(43):16549-54
Hunting for predictive computational drug-discovery models.
Snow CD

Expert review of anti-infective therapy. 2008 Jun;6(3):291-3
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.
Li Y, Drummond DA, Sawayama AM, Snow CD, Bloom JD, Arnold FH

Nature biotechnology. 2007 Sep;25(9):1051-6
Electric fields at the active site of an enzyme: direct comparison of experiment with theory.
Suydam IT, Snow CD, Pande VS, Boxer SG

Science (New York, N.Y.). 2006 Jul 14;313(5784):200-4
Kinetic definition of protein folding transition state ensembles and reaction coordinates.
Snow CD, Rhee YM, Pande VS

Biophysical journal. 2006 Jul 1;91(1):14-24
Direct calculation of the binding free energies of FKBP ligands.
Fujitani H, Tanida Y, Ito M, Jayachandran G, Snow CD, Shirts MR, Sorin EJ, Pande VS

The Journal of chemical physics. 2005 Aug 22;123(8):084108
Dimerization of the p53 oligomerization domain: identification of a folding nucleus by molecular dynamics simulations.
Chong LT, Snow CD, Rhee YM, Pande VS

Journal of molecular biology. 2005 Jan 28;345(4):869-78
How well can simulation predict protein folding kinetics and thermodynamics?
Snow CD, Sorin EJ, Rhee YM, Pande VS

Annual review of biophysics and biomolecular structure. 2005;34:43-69
Using path sampling to build better Markovian state models: predicting the folding rate and mechanism of a tryptophan zipper beta hairpin.
Singhal N, Snow CD, Pande VS

The Journal of chemical physics. 2004 Jul 1;121(1):415-25
Trp zipper folding kinetics by molecular dynamics and temperature-jump spectroscopy.
Snow CD, Qiu L, Du D, Gai F, Hagen SJ, Pande VS

Proceedings of the National Academy of Sciences of the United States of America. 2004 Mar 23;101(12):4077-82
Surface salt bridges, double-mutant cycles, and protein stability: an experimental and computational analysis of the interaction of the Asp 23 side chain with the N-terminus of the N-terminal domain of the ribosomal protein l9.
Luisi DL, Snow CD, Lin JJ, Hendsch ZS, Tidor B, Raleigh DP

Biochemistry. 2003 Jun 17;42(23):7050-60
Atomistic protein folding simulations on the submillisecond time scale using worldwide distributed computing.
Pande VS, Baker I, Chapman J, Elmer SP, Khaliq S, Larson SM, Rhee YM, Shirts MR, Snow CD, Sorin EJ, Zagrovic B

Biopolymers. 2003 Jan;68(1):91-109
The Trp cage: folding kinetics and unfolded state topology via molecular dynamics simulations.
Snow CD, Zagrovic B, Pande VS

Journal of the American Chemical Society. 2002 Dec 11;124(49):14548-9
Absolute comparison of simulated and experimental protein-folding dynamics.
Snow CD, Nguyen H, Pande VS, Gruebele M

Nature. 2002 Nov 7;420(6911):102-6
Simulation of folding of a small alpha-helical protein in atomistic detail using worldwide-distributed computing.
Zagrovic B, Snow CD, Shirts MR, Pande VS

Journal of molecular biology. 2002 Nov 8;323(5):927-37
Native-like mean structure in the unfolded ensemble of small proteins.
Zagrovic B, Snow CD, Khaliq S, Shirts MR, Pande VS

Journal of molecular biology. 2002 Oct 11;323(1):153-64

One Figure

Direct comparison for ultrafast protein folding kinetics and enzyme electrostatics (a) Measuring the rate constant using early transitions from a single exponential folding process. (b) Three polypeptides that fold on the microsecond timescale by temperat

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