Epernicus: Christopher B. Phelps, Ph.D.

Christopher B. Phelps, Ph.D.

Position:
Investigator

Platform and Technology Science

GlaxoSmithKline (London, UK)
Degrees:

Ph.D., Chemistry, University of California, San Diego (San Diego, CA)

M.S., Chemistry, University of California, San Diego (San Diego, CA)

B.Sc., Biology, St. Lawrence University (Canton, NY)
Past Advisors:

Rachelle Gaudet (as Post Doctoral Fellow)

Gourisankar Ghosh (as Graduate Student - Ph.D.)

Nadia Marano (as Undergraduate Student)
Research:
I am working on the application of Encoded Library Technology to help discover novel compounds targeting ion channels and other plasma membrane proteins.

Communities:

Christopher Phelps's Genealogy

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Christopher Phelps's Publications (14)

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C.
Landouré G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH, Choo SS, Phelps CB, Paudel R, Houlden H, Ludlow CL, Caterina MJ, Gaudet R, Kleta R, Fischbeck KH, Sumner CJ

Nature genetics. 2010 Feb;42(2):170-4
Differential regulation of TRPV1, TRPV3 AND TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.
Phelps CB, Wang RR, Choo SS, Gaudet R

The Journal of biological chemistry. 2009 Oct 28
Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels.
Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R

Biochemistry. 2008 Feb 26;47(8):2476-84
The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization.
Phelps CB, Gaudet R

The Journal of biological chemistry. 2007 Dec 14;282(50):36474-80
The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity.
Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R

Neuron. 2007 Jun 21;54(6):905-18
Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels.
Phelps CB, Procko E, Lishko PV, Wang RR, Gaudet R

Channels (Austin, Tex.). 2007 May-Jun;1(3):148-51
Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB.
Huang DB, Phelps CB, Fusco AJ, Ghosh G

Journal of molecular biology. 2005 Feb 11;346(1):147-60
Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity.
Phelps CB, Ghosh G

Oncogene. 2004 Feb 12;23(6):1229-38
Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation.
Huxford T, Mishler D, Phelps CB, Huang DB, Sengchanthalangsy LL, Reeves R, Hughes CA, Komives EA, Ghosh G

Journal of molecular biology. 2002 Dec 6;324(4):587-97
X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.
Huang DB, Chen YQ, Ruetsche M, Phelps CB, Ghosh G

Structure (London, England : 1993). 2001 Aug;9(8):669-78
Differential binding of cAMP-dependent protein kinase regulatory subunit isoforms Ialpha and IIbeta to the catalytic subunit.
Cheng X, Phelps C, Taylor SS

The Journal of biological chemistry. 2001 Feb 9;276(6):4102-8
Mechanism of I kappa B alpha binding to NF-kappa B dimers.
Phelps CB, Sengchanthalangsy LL, Huxford T, Ghosh G

The Journal of biological chemistry. 2000 Sep 22;275(38):29840-6
Mechanism of kappa B DNA binding by Rel/NF-kappa B dimers.
Phelps CB, Sengchanthalangsy LL, Malek S, Ghosh G

The Journal of biological chemistry. 2000 Aug 11;275(32):24392-9
Construction, expression, purification and functional analysis of recombinant NFkappaB p50/p65 heterodimer.
Chen FE, Kempiak S, Huang DB, Phelps C, Ghosh G

Protein engineering. 1999 May;12(5):423-8

Christopher Phelps's Posters and Presentations (1)

Regulation of TRPV Activity through their Ankyrin Repeat Domains (poster)
Christopher B. Phelps

Gordon Research Conference, Calcium Signalling; 08/2007

One Figure

The sensitivity of the TRPV1, 3, and 4 ion channels is modulated by the mutually exclusive binding of ATP and Calmodulin to a conserved site in a cytoplasmic ankyrin repeat domain.

Websites

Guadet Lab Home Page

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