Brandon S Russell

Brandon S Russell, B.S.

(Ph.D. in progress)
  • Position:
    Graduate Student - Ph.D.

    Biological Engineering

    Massachusetts Institute of Technology (Cambridge, MA)

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  • Advisor:

    Peter Dedon

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  • Degrees:
     
    Ph.D. (in progress), Biological Engineering, Massachusetts Institute of Technology (Cambridge, MA)
     
    B.S., Chemistry, University of Mississippi (Lafayette, MS)
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  • Past Advisors:
     
    Daniell Mattern (as Undergraduate Student)
     
    Thedford Keith Hollis (as Undergraduate Student)
     
    Peter Dedon (as Visiting Student)
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  • Research:
    Investigating the scope and function of endogenous RNA secondary modifications in human pathogens exposed to oxidative stress

    In addition to the five canonical nucleoside bases (adenine, guanine, thymine, cytosine, and uracil), more than 100 modified bases have been discovered from all domains of life. These are produced by enzymatic modification of the canonical bases, and can be found throughout tRNA, helping establish its unique secondary structure. Identification of modified bases unique to human pathogens could lead to the development of novel biomarkers of infection. In addition, modification of the wobble base in the anticodon loop can enhance the affinity of a charged tRNA for its cognate mRNA, thereby increasing translational efficiency and biasing the production of proteins enriched for a given codon. Characterizing such systems in human pathogens could reveal novel therapeutic targets.

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  • Other Experience:

    2008-2010 MIT Graduate Student Teaching Certificate Program

    2009 Massachusetts EMT-Basic Certification

    2006-2007 UM Organic Chemistry Teaching Assistant

    2006 UM General Chemistry Laboratory Teaching Assistant

    2006 MIT ABS REU Summer Internship

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  • Honors:

    2009-2012 NSF Graduate Research Fellowship

    2008-2009 Eni-MIT Energy Fellowship

    2007 Barry M. Goldwater Scholarship

    2007 Phi Beta Kappa Honor Society

    2006 Phi Kappa Phi Honor Society

    2004-2008 National Merit Scholar

    2003 Eagle Scout

Life Sciences
Communities:

Brandon Russell's Genealogy

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Brandon Russell's Posters and Presentations (2)

  • Nanostructure Properties of Simple Organic and Organometallic Compounds (poster)

    Brandon S Russell and T. Keith Hollis

    University of Mississippi, Sigma Xi Annual Poster Symposium; 04/2007
  • The Relationship Between DNA Adduct Formation and Cytotoxicity in Human HCT116 Cells Exposed to Toxic Levels of Nitric Oxide (poster)

    Brandon S. Russell, C. Eric Elmquist, Laura J. Trudel, and Peter C. Dedon

    Biomedical Engineering Society, Annual Fall Conference; 10/2006

One Figure

One Figure for Brandon S Russell

Final figure from my undergraduate honors thesis, showing that HCT116 cells develop only modest levels of DNA adducts when exposed to toxic levels of nitric oxide.


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