Britney L Moss

Britney L Moss, B.Sc.

(Ph.D. in progress)
  • Position:
    Graduate Student - Ph.D.

    Biology and Biomedical Sciences

    Radiology

    Washington University in St. Louis (Saint Louis, MO)

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  • Advisor:

    David R. Piwnica-Worms

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  • Degrees:
     
    Ph.D. (in progress), Molecular Cell Biology, Washington University in St. Louis (Saint Louis, MO)
     
    B.Sc., Biochemistry, Montana State University (Bozeman, MT)
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  • Past Advisors:
     
    Charles Spangler (as Technician)
     
    Jean Starkey (as Undergraduate Student)
     
    Mary Miles (as Undergraduate Student)
     
    Brenda Spangler (as Visiting Student)
     
    Susan Hardin (as Visiting Student)
     
    Jill M Kolesar (as Visiting Student)
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  • Research:
    I use biouminescence imaging techniques as a means to study regulation with the NF-kB pathway.

    My current research focuses on using bioluminescent imaging as a tool to study how cells interpret signals from their environment and funnel this information through critical signaling networks within cells. The signaling pathway I am currently studying, the NF-kB pathway, is involved in mediating immune and inflammation responses and is often a contributing factor to the progression of cancerous growth. I am investigating potential mechanisms that regulate the activity of key proteins in the NF-kB pathway by using fusion protein reporters. My work has utilized in cellulo bioluminescent imaging of an IkBa-FLuc reporter (the inhibitor of NF-kB protein fused to the firefly luciferase enzyme), in vitro kinase assays, biochemical techniques, and computational modeling to probe the dynamic properties of NF-kB signaling and to fully characterize the many levels of regulation that govern this pathway.

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  • Other Experience:
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  • Honors:

    2006-present NSF Graduate Research Fellowship

    2007 Aspen Cancer Conference Fellow

    2002-2004 Barry M. Goldwater Scholarship

Life Sciences
Communities:

Britney Moss's Genealogy

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Britney Moss's Publications (3)



Britney Moss's Posters and Presentations (5)

  • Ligand-Induced Transient Desensitization of NF-κB Signaling. (poster)

    Moss BL, Gross S, Gammon ST, and Piwnica-Worms D

    Joint Molecular Imaging Conference; 09/2007
  • Transient Desensitization of Ligand-Dependent NF-kappaB Signaling. (poster)

    Moss BL, Gross S, Gammon ST, and Piwnica-Worms D

    Aspen Cancer Conference; 07/2007
  • Synthesis, characterization and preclinical studies of targeted photo-dynamic therapy agents activated in the tissue transparency window (poster)

    Starkey JR, Meng F, Gong A, Moss BL, Rebane A, Drobizhev M and Spangler CW

    American Association of Cancer Research; 04/2005
  • Laminin binding protein shed from malignant tumor cells may block angiostatin production (presentation)

    Moss BL, Kazmin D, and Starkey JR

    Montana Chapter of the American Chemical Society , Meeting in; 03/2003
  • Laminin binding protein shed from malignant tumor cells may block angiostatin production (poster)

    Moss BL, Kazmin D, and Starkey JR

    FASEB Experimental Biology; 04/2002

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