Alexander T Honkala

Alexander T Honkala, B.S.

  • Position:
    Research Associate

    Department of Microbiology and Immunology

    University of Michigan Medical School (Ann Arbor, MI)

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  • Advisor:

    Mary X.D. O'Riordan

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  • Degrees:
     
    B.S., Cell and Molecular Biology, University of Michigan College of Literature, Science, and the Arts (Ann Arbor, MI)
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  • Past Advisors:
     
    Kathryn A. Eaton (as Technician)
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  • Research:
    Delineating role of XIAP in proliferative and apoptotic behavior in adaptive immune system populations.

    The rare absence of XIAP in human patients has been linked to X-linked lymphoproliferative disorder, which often results in fulminant mononucleosis. Surviving patients are found to have abnormal proliferative dynamics of the adaptive immune system, and dysregulated expression of XIAP has also been linked to a wide variety of cancers. Mice lacking XIAP have been found to be significantly more susceptible to intracellular pathogen challenge by Listeria monocytogenes, and it has been further found that bulk splenocytes from these mice undergo markedly increased proliferation upon T-cell receptor stimulation. I am currently trying to better characterize the stimulatory factors and specific immune cell populations involved in this differential proliferation.

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Life Sciences
Communities:

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One Figure

One Figure for Alexander T Honkala

Cecal section of germ-free mouse infected 1 week with EHEC. Red is actin, green is EHEC.


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