Epernicus: Agata Smogorzewska, M.D., Ph.D.

Agata Smogorzewska, M.D., Ph.D.

Position:
Assistant Professor

Laboratory of Genome Maintenance

The Rockefeller University (New York, NY)
Degrees:

M.D., Weill Cornell Medical College (New York, NY)

Ph.D., The Rockefeller University (New York, NY)
Clinical Training:

Residency, Clinical Pathology, Massachusetts General Hospital
Past Advisors:

Stephen J. Elledge (as Post Doctoral Fellow)

Titia de Lange (as Graduate Student - Ph.D.)

Judith Campisi (as Undergraduate Student)

Richard Deonier (as Undergraduate Student)
Research:
Honors:
2008 Burroughs Wellcome Fund Career Award for Medical Scientists

2007 Fanconi Anemia Research Fund Discovery Award

2007 Keystone Scholarship Award

2007 Clinical Research Day Pathology Service Award

2007 Poster of Distinction Award: 31st Annual MGH Research Symposium

2002 Prize for Promise- 1st runner-up

2001 Keystone Scholarship Award

1997 American Society of Clinical Pathologist’s Award

1995 Okin Scholarship in Biological Sciences

1995 Milo Don Apellman, Jr. Award

1994 US Dept. of Energy sponsored Science and Engineering Research Semester

1993 HHMI Summer Research Scholarship in Biological Research

Communities:

Agata Smogorzewska's Genealogy

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Agata Smogorzewska's Publications (20)

The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC

Science (New York, N.Y.). 2009 Dec 18;326(5960):1698-701
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW

Cell. 2009 Jul 10;138(1):63-77
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M

Nature structural & molecular biology. 2008 Nov;15(11):1138-46
Cancer proliferation gene discovery through functional genomics.
Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ

Science (New York, N.Y.). 2008 Feb 1;319(5863):620-4
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ

Science (New York, N.Y.). 2007 May 25;316(5828):1194-8
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ

Science (New York, N.Y.). 2007 May 25;316(5828):1160-6
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ

Cell. 2007 Apr 20;129(2):289-301
Postmortem urine immunoassay showing false-positive phencyclidine reactivity in a case of fatal tramadol overdose.
Hull MJ, Griggs D, Knoepp SM, Smogorzewska A, Nixon A, Flood JG

The American journal of forensic medicine and pathology : official publication of the National Association of Medical Examiners. 2006 Dec;27(4):359-62
Effect of fondaparinux on coagulation assays: results of College of American Pathologists proficiency testing.
Smogorzewska A, Brandt JT, Chandler WL, Cunningham MT, Hayes TE, Olson JD, Kottke-Marchant K, Van Cott EM

Archives of pathology & laboratory medicine. 2006 Nov;130(11):1605-11
Transfusion medicine illustrated. Volume-reduced apheresis platelets.
Smogorzewska A, Dzik W

Transfusion. 2005 May;45(5):651
Homologous recombination generates T-loop-sized deletions at human telomeres.
Wang RC, Smogorzewska A, de Lange T

Cell. 2004 Oct 29;119(3):355-68
Paraprotein interference in automated chemistry analyzers.
Smogorzewska A, Flood JG, Long WH, Dighe AS

Clinical chemistry. 2004 Sep;50(9):1691-3
Regulation of telomerase by telomeric proteins.
Smogorzewska A, de Lange T

Annual review of biochemistry. 2004;73:177-208
DNA damage foci at dysfunctional telomeres.
Takai H, Smogorzewska A, de Lange T

Current biology : CB. 2003 Sep 2;13(17):1549-56
DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2.
Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T

Current biology : CB. 2002 Oct 1;12(19):1635-44
Different telomere damage signaling pathways in human and mouse cells.
Smogorzewska A, de Lange T

The EMBO journal. 2002 Aug 15;21(16):4338-48
Senescence induced by altered telomere state, not telomere loss.
Karlseder J, Smogorzewska A, de Lange T

Science (New York, N.Y.). 2002 Mar 29;295(5564):2446-9
Control of human telomere length by TRF1 and TRF2.
Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T

Molecular and cellular biology. 2000 Mar;20(5):1659-68
TRF2 protects human telomeres from end-to-end fusions.
van Steensel B, Smogorzewska A, de Lange T

Cell. 1998 Feb 6;92(3):401-13
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
Broccoli D, Smogorzewska A, Chong L, de Lange T

Nature genetics. 1997 Oct;17(2):231-5

Websites

Smogorzewska Lab Page

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Agata Smogorzewska, M.D., Ph.D.

Assistant Professor

Agata Smogorzewska's Genealogy

Agata Smogorzewska's Publications (20)

Websites