Epernicus: Albert M. Berghuis, Ph.D.

Albert M. Berghuis, Ph.D.

Position:
Professor

Biochemistry

Microbiology & Immunology

McGill University (Montreal, Canada)
Degrees:

Ph.D., Biochemistry, University of British Columbia (Vancouver, Canada)
Past Advisors:

Stephen R. Sprang (as Post Doctoral Fellow)

Gary D. Brayer (as Graduate Student - Ph.D.)

Wim G.J. Hol (as Graduate Student - Masters)
Research:
Honors:
2002-present Canada Research Chair in Structural Biology

Communities:

Albert Berghuis's Genealogy

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Albert Berghuis's Publications (48)

The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation.
Xiong B, Burk DL, Shen J, Luo X, Liu H, Shen J, Berghuis AM

Proteins. 2008 Jun;71(4):1984-94
Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO.
Miller WL, Matewish MJ, McNally DJ, Ishiyama N, Anderson EM, Brewer D, Brisson JR, Berghuis AM, Lam JS

The Journal of biological chemistry. 2008 Feb 8;283(6):3507-18
Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae.
Burk DL, Hwang J, Kwok E, Marrone L, Goodfellow V, Dmitrienko GI, Berghuis AM

Journal of molecular biology. 2007 Oct 26;373(3):745-54
Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.
Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, Gehring K

Molecular cell. 2007 Aug 3;27(3):474-85
Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase.
Korczynska M, Mukhtar TA, Wright GD, Berghuis AM

Proceedings of the National Academy of Sciences of the United States of America. 2007 Jun 19;104(25):10388-93
Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence.
Nascimento M, Zhang WW, Ghosh A, Houston DR, Berghuis AM, Olivier M, Matlashewski G

The Journal of biological chemistry. 2006 Nov 24;281(47):36257-68
Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity.
Ishiyama N, Creuzenet C, Miller WL, Demendi M, Anderson EM, Harauz G, Lam JS, Berghuis AM

The Journal of biological chemistry. 2006 Aug 25;281(34):24489-95
Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases.
Gao F, Yan X, Shakya T, Baettig OM, Ait-Mohand-Brunet S, Berghuis AM, Wright GD, Auclair K

Journal of medicinal chemistry. 2006 Aug 24;49(17):5273-81
Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism.
Fong DH, Yim VC, D'Elia MA, Brown ED, Berghuis AM

Biochimica et biophysica acta. 2006 Jan;1764(1):63-9
Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases.
Mirza IA, Nazi I, Korczynska M, Wright GD, Berghuis AM

Biochemistry. 2005 Dec 6;44(48):15768-73
Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.
Christensen KE, Mirza IA, Berghuis AM, Mackenzie RE

The Journal of biological chemistry. 2005 Oct 7;280(40):34316-23
Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases.
Gao F, Yan X, Baettig OM, Berghuis AM, Auclair K

Angewandte Chemie (International ed. in English). 2005 Oct 28;44(42):6859-62
Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses.
Burk DL, Xiong B, Breitbach C, Berghuis AM

Acta crystallographica. Section D, Biological crystallography. 2005 Sep;61(Pt 9):1273-9
Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP.
Demendi M, Ishiyama N, Lam JS, Berghuis AM, Creuzenet C

The Biochemical journal. 2005 Jul 1;389(Pt 1):173-80
Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila.
Lemke CT, Hwang J, Xiong B, Cianciotto NP, Berghuis AM

Acta crystallographica. Section F, Structural biology and crystallization communications. 2005 Jun 1;61(Pt 6):606-8
A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni.
Bernatchez S, Szymanski CM, Ishiyama N, Li J, Jarrell HC, Lau PC, Berghuis AM, Young NM, Wakarchuk WW

The Journal of biological chemistry. 2005 Feb 11;280(6):4792-802
Crystallization and preliminary crystallographic analysis of 3'-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7.
Fong DH, Berghuis AM

Acta crystallographica. Section D, Biological crystallography. 2004 Oct;60(Pt 10):1897-9
New phenolic inhibitors of yeast homoserine dehydrogenase.
Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD

Bioorganic & medicinal chemistry. 2004 Jul 15;12(14):3825-30
Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: substrate specificity in udp-hexose 4-epimerases.
Ishiyama N, Creuzenet C, Lam JS, Berghuis AM

The Journal of biological chemistry. 2004 May 21;279(21):22635-42
Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase.
Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, Kinach R, Honek JF, Lai HK, Berghuis AM, Wright GD

Chemistry & biology. 2003 Oct;10(10):989-95
X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members.
Burk DL, Ghuman N, Wybenga-Groot LE, Berghuis AM

Protein science : a publication of the Protein Society. 2003 Mar;12(3):426-37
YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics.
Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED

Biochemistry. 2002 Sep 17;41(37):11109-17
Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop.
Thompson PR, Boehr DD, Berghuis AM, Wright GD

Biochemistry. 2002 Jun 4;41(22):7001-7
Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry.
Fong DH, Berghuis AM

The EMBO journal. 2002 May 15;21(10):2323-31
Protein kinase inhibitors and antibiotic resistance.
Burk DL, Berghuis AM

Pharmacology & therapeutics. 2002 Feb-Mar;93(2-3):283-92

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Albert M. Berghuis, Ph.D.

Professor

Albert Berghuis's Genealogy

Albert Berghuis's Publications (48)