Epernicus: Amber L Wells, Ph.D.

Amber L Wells, Ph.D.

Position:
Assistant Professor

Department of Medicine, Division of Cardiology

Department of Anatomy & Structural Biology

Albert Einstein College of Medicine of Yeshiva University
Degrees:

Ph.D., Cell and Molecular Biology, University of Pennsylvania School of Medicine (Philadelphia, PA)

B.S., Physiological Science, University of California, Los Angeles (Los Angeles, CA)
Past Advisors:

Robert H. Singer (as Post Doctoral Fellow)

John Condeelis (as Post Doctoral Fellow)

Anne Houdusse (as Visiting Student)

H. Lee Sweeney (as Graduate Student - Ph.D.)

James G. Tidball (as Undergraduate Student)
Research:
Other Experience:
1994-1995 Instrument evaluator / clinical chemistry scientist, Beckman Instruments, Fullerton, CA

1993 Quality Control and analytical chemistry technician, Hauser Chemical Research, Boulder, CO
Honors:
2008-2010 Muscular Dystrophy Association Development Grant

2001-2002 Chateaubriand Fellowship, Paris, France

1992 Physiological Science Departmental Honors, UCLA

1992 President's Undergraduate Fellowship, UCLA

1992 College Honors Summer Research Stipend, UCLA

Communities:

Amber Wells's Genealogy

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Amber Wells's Publications (16)

Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells.
Gu W, Wells AL, Pan F, Singer RH

Molecular and cellular biology. 2008 Aug;28(16):4963-74
Imaging Real-Time Gene Expression in Living Systems. Laboratory Manual for Single Molecule Studies.
Amber L Wells , Jon S Condeelis , Robert H Singer, Daniel Zenklusen

Cold Spring Harbor Laboratory Press. 2008;ISBN 978-087969775-4
Biochemical and structural characterization of the gem GTPase.
Splingard A, Ménétrey J, Perderiset M, Cicolari J, Regazzoni K, Hamoudi F, Cabanié L, El Marjou A, Wells A, Houdusse A, de Gunzburg J

The Journal of biological chemistry. 2007 Jan 19;282(3):1905-15
Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site.
Chevreux G, Potier N, Van Dorsselaer A, Bahloul A, Houdusse A, Wells A, Sweeney HL

Journal of the American Society for Mass Spectrometry. 2005 Aug;16(8):1367-76
The structure of the myosin VI motor reveals the mechanism of directionality reversal.
Ménétrey J, Bahloul A, Wells AL, Yengo CM, Morris CA, Sweeney HL, Houdusse A

Nature. 2005 Jun 9;435(7043):779-85
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.
Wang W, Goswami S, Lapidus K, Wells AL, Wyckoff JB, Sahai E, Singer RH, Segall JE, Condeelis JS

Cancer research. 2004 Dec 1;64(23):8585-94
The unique insert in myosin VI is a structural calcium-calmodulin binding site.
Bahloul A, Chevreux G, Wells AL, Martin D, Nolt J, Yang Z, Chen LQ, Potier N, Van Dorsselaer A, Rosenfeld S, Houdusse A, Sweeney HL

Proceedings of the National Academy of Sciences of the United States of America. 2004 Apr 6;101(14):4787-92
A structural state of the myosin V motor without bound nucleotide.
Coureux PD, Wells AL, Ménétrey J, Yengo CM, Morris CA, Sweeney HL, Houdusse A

Nature. 2003 Sep 25;425(6956):419-23
Calcium functionally uncouples the heads of myosin VI.
Morris CA, Wells AL, Yang Z, Chen LQ, Baldacchino CV, Sweeney HL

The Journal of biological chemistry. 2003 Jun 27;278(26):23324-30
An actin-dependent conformational change in myosin.
Xiao M, Reifenberger JG, Wells AL, Baldacchino C, Chen LQ, Ge P, Sweeney HL, Selvin PR

Nature structural biology. 2003 May;10(5):402-8
Myosin VI is a processive motor with a large step size.
Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL

Proceedings of the National Academy of Sciences of the United States of America. 2001 Nov 20;98(24):13655-9
Actin and light chain isoform dependence of myosin V kinetics.
De La Cruz EM, Wells AL, Sweeney HL, Ostap EM

Biochemistry. 2000 Nov 21;39(46):14196-202
Kinetic and spectroscopic evidence for three actomyosin:ADP states in smooth muscle.
Rosenfeld SS, Xing J, Whitaker M, Cheung HC, Brown F, Wells A, Milligan RA, Sweeney HL

The Journal of biological chemistry. 2000 Aug 18;275(33):25418-26
The kinetic mechanism of myosin V.
De La Cruz EM, Wells AL, Rosenfeld SS, Ostap EM, Sweeney HL

Proceedings of the National Academy of Sciences of the United States of America. 1999 Nov 23;96(24):13726-31
Myosin VI is an actin-based motor that moves backwards.
Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL

Nature. 1999 Sep 30;401(6752):505-8
In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes.
Haecker SE, Stedman HH, Balice-Gordon RJ, Smith DB, Greelish JP, Mitchell MA, Wells A, Sweeney HL, Wilson JM

Human gene therapy. 1996 Oct 1;7(15):1907-14

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Amber L Wells, Ph.D.

Assistant Professor

Amber Wells's Genealogy

Amber Wells's Publications (16)

Websites