Abraham L Brass, M.D., Ph.D.
- Position:
Assistant Professor
Ragon Institute of Mass. General Hosp. (MGH), MIT and Harvard University
Gastroenterology Unit MGH
Harvard Medical School (Boston, MA)
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Degrees:
M.D., University of Chicago (Chicago, IL)Ph.D., Molecular Genetics and Cell Biology, University of Chicago (Chicago, IL)
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Clinical Training:
Fellowship, Gastroenterology, Massachusetts General HospitalResidency, Internal Medicine, Brigham and Women's Hospital
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Past Advisors:
Stephen J. Elledge (as Post Doctoral Fellow)Harinder Singh (as Graduate Student - Ph.D.)
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Research:
We use multiple modalities to discover and define host cell modifiers of viral infection (dependency and restriction factors).
Viruses exploit host factors to replicate. However, each of these interactions also represents a viral weakness that may be targeted to combat infection. Functional genomics represents a powerful methodology for uncovering such viral dependency factors. By combining the human genome sequencing project and the technology of RNAi, we can specifically deplete each human gene product, and subsequently test if loss of that factor impacts viral replication. Combined with proteomics, as well as conventional molecular genetic and biochemical approaches, functional genomics promises to greatly increase our knowledge of host-viral interactions, and further our goal of alleviating human suffering by defeating these pathogens.
Abraham Brass's Genealogy
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Abraham Brass's Publications (13)
One Figure
IFITM Proteins Act as Antiviral Restriction Factors:
A model of the influenza A virus life cycle, the induction of IFITM proteins, and their role in blocking Influenza A virus infection.
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