Alexander Loewer

Alexander Loewer, Ph.D.

  • Position:
    Post Doctoral Fellow

    Systems Biology

    Harvard Medical School (Boston, MA)

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  • Advisor:

    Galit Lahav

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  • Degrees:
     
    Ph.D., Biology, Heidelberg University (Heidelberg, Germany)
     
    M.S., Biology, Heidelberg University (Heidelberg, Germany)
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  • Past Advisors:
     
    Renato Paro (as Graduate Student - Ph.D.)
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  • Research:
    I currently study protein dynamics in signal transduction in single living cells.

    The tumor suppressor protein p53, a key player in DNA damage signaling, is regulated by various feedback loops. The architecture of these feedbacks shapes the dynamic response of the pathway. Ionizing radiation, for instance, induces periodic p53 pulses. My research focuses on three projects: First, I am investigating the quantitative relation between DNA damage and the p53 response. Furthermore, I aim to understand how the architecture of the signaling network shapes its dynamic response to different conditions. Finally, I am studying how the dynamics of p53 influence the cellular response to DNA damage. To achieve these goals, I quantitatively measure protein dynamics with high temporal resolution in single living human cells and combine the resulting data with mathematical models.

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  • Honors:

    1999-2001 German National Academic Foundation (Studienstiftung des Deutschen Volkes))

Life Sciences
Communities:

Alexander Loewer's Genealogy

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Alexander Loewer's Publications (4)



Alexander Loewer's Posters and Presentations (1)

  • p53 dynamics in non-stressed conditions (presentation)

    Alexander Loewer and Galit Lahav

    q-bio conference on cellular information processing; 08/2008

One Figure

One Figure for Alexander Loewer

p53 pulses in non-stressed conditions do not lead to activation of p21. A) Diagram of p53 and p21 fluorescent reporter constructs. B-C) Time-lapse images of dual reporter cells in non-stressed conditions (B) or after damage induction with 400ng/ml NCS (C)


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