Amanda C Nottke

Amanda C Nottke, B.Sc.

(Ph.D. in progress)
  • Position:
    Graduate Student - Ph.D.

    Pathology

    Genetics

    Harvard Medical School (Boston, MA)

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  • Advisors:

    Monica P. Colaiacovo, Yang Shi

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  • Degrees:
     
    Ph.D. (in progress), Biological and Biomedical Sciences, Harvard Medical School (Boston, MA)
     
    B.Sc., Biology, University of Oregon (Eugene, OR)
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  • Past Advisors:
     
    Richard H. Goodman (as Technician)
     
    Qinghong Zhang (as Technician)
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  • Research:
    I am exploring biological roles for the histone lysine demethylases using C. elegans as a model.

    The DNA-packaging histone proteins can be post-translationally modified in a variety of ways, including lysine methylation. The degree and position of methylation on the histone tail can lead to dramatically different biological outputs. For example, dimethylation of Histone H3 lysine 9 (H3K9me2) is associated with heterochromatin, whereas H3K4me3 peaks over active promoters. Removal of histone methylation is enyzmatically mediated by the lysine histone demethylases (or KDMs).

    The first KDM (LSD1/KDM1) was identified in the Shi lab in 2004, and I am currently working on describing a novel role for the C. elegans homolog in meiotic DNA damage response.

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  • Other Experience:

    2008-present Seeding Labs (Equipping Science in the Developing World)

    2007-present Mentoring for Science (8th Graders)

    2006-present Science in the News (SITN) - lecturer, writer

Life Sciences
Communities:

Amanda Nottke's Genealogy

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Amanda Nottke's Publications (5)



Amanda Nottke's Posters and Presentations (2)

  • Exploring the Biological Roles of the Histone Demethylase LSD1 (poster)

    Amanda C Nottke

    C. elegans Development & Evolution Meeting; 06/2008
  • Exploring the Biological Roles of the Histone Demethylase LSD1 (poster)

    Amanda C Nottke

    16th Internation C. elegans Meeting; 06/2007

One Figure

One Figure for Amanda C Nottke

As nuclei progress (left to right) through meiotic prophase I, they can be unambiguously identified by both morphology and position within the dissected C. elegans gonad.


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