
Biology
Brandeis University (Waltham, MA)
My research goal is to understand how neurons undergo morphological change in response to environmental and activity-dependent signaling cues. The receptors that transduce synaptic growth signals are regulated by endocytic recycling, but we do not understand what internal compartments they signal from, what special properties of those compartments enable signaling to occur, and ultimately how the membrane traffic machinery itself can be regulated to control synaptic growth. I use a combination of biochemistry, genetics, and cell biology in Drosophila to unravel the molecular mechanisms by which conserved membrane remodeling proteins respond to developmental and activity-dependent cues to modify synaptic architecture.

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